Cargando…

Tanshinone IIA Downregulates Lipogenic Gene Expression and Attenuates Lipid Accumulation through the Modulation of LXRα/SREBP1 Pathway in HepG2 Cells

Abnormal and excessive accumulation of lipid droplets within hepatic cells is the main feature of steatosis and nonalcoholic fatty liver disease (NAFLD) or metabolic-associated fatty liver disease (MAFLD). Dysregulation of lipogenesis contributes to hepatic steatosis and plays an essential role in t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Wan-Yun, Chen, Pei-Yi, Hsu, Hao-Jen, Lin, Ching-Yen, Wu, Ming-Jiuan, Yen, Jui-Hung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004631/ https://www.ncbi.nlm.nih.gov/pubmed/33806955 http://dx.doi.org/10.3390/biomedicines9030326

Ejemplares similares

Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells
por: Chen, Hung-Chen, et al.
Publicado: (2016)

Simultaneous induction of apoptosis and necroptosis by Tanshinone IIA in human hepatocellular carcinoma HepG2 cells
por: Lin, C-Y, et al.
Publicado: (2016)

MicroRNA-613 represses lipogenesis in HepG2 cells by downregulating LXRα
por: Zhong, Dan, et al.
Publicado: (2013)

Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats
por: Yan, Jun, et al.
Publicado: (2016)

Effect of Supplementation of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate on the Anticancer Effect of Epirubicin: An In Vitro Study
por: Chan, Szu-Erh, et al.
Publicado: (2011)

Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats
por: HE, HUANYU, et al.
Publicado: (2015)

Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA
por: Shen, Jui-Lung, et al.
Publicado: (2011)

Comparative Effects of Fructose and Glucose on Lipogenic Gene Expression and Intermediary Metabolism in HepG2 Liver Cells
por: Hirahatake, Kristin M., et al.
Publicado: (2011)

Effects of Tanshinone IIA on the modulation of miR-33a and the SREBP-2/Pcsk9 signaling pathway in hyperlipidemic rats
por: JIA, LIANQUN, et al.
Publicado: (2016)

Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia
por: Zhong, Liren, et al.
Publicado: (2020)

Magma Seawater Inhibits Hepatic Lipid Accumulation through Suppression of Lipogenic Enzymes Regulated by SREBPs in Thioacetamide-Injected Rats
por: Woo, Minji, et al.
Publicado: (2019)

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells
por: Zhang, Jun, et al.
Publicado: (2013)

Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1
por: Yu, Jiao, et al.
Publicado: (2017)

Astragaloside IV Inhibits Triglyceride Accumulation in Insulin-Resistant HepG2 Cells via AMPK-Induced SREBP-1c Phosphorylation
por: Wang, Chunyi, et al.
Publicado: (2018)

Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones
por: Zhai, Xifeng, et al.
Publicado: (2017)

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells
por: Iio, Akio, et al.
Publicado: (2013)

Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice
por: Yang, Xin-Jing, et al.
Publicado: (2018)

Corrigendum to “Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia”
por: Zhong, Liren, et al.
Publicado: (2020)

Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation
por: Wen, Jiexia, et al.
Publicado: (2020)

Mechanism of AMPK Suppression of LXR-dependent Srebp-1c Transcription
por: Yap, Fuichi, et al.
Publicado: (2011)

Tanshinone IIA reverses EGF- and TGF-β1-mediated epithelial-mesenchymal transition in HepG2 cells via the PI3K/Akt/ERK signaling pathway
por: Zhang, Longkai, et al.
Publicado: (2019)

Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells
por: Hasei, Shun, et al.
Publicado: (2021)

The Lipid-Modulating Effect of Tangeretin on the Inhibition of Angiopoietin-like 3 (ANGPTL3) Gene Expression through Regulation of LXRα Activation in Hepatic Cells
por: Chen, Pei-Yi, et al.
Publicado: (2021)

Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation
por: Forbes-Hernández, Tamara Y., et al.
Publicado: (2017)

Piceatannol attenuates fat accumulation and oxidative stress in steatosis-induced HepG2 cells
por: Yang, Jason Szuhao, et al.
Publicado: (2020)

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice
por: Rong, Shunxing, et al.
Publicado: (2017)

The Attenuation of Traumatic Brain Injury via Inhibition of Oxidative Stress and Apoptosis by Tanshinone IIA
por: Huang, Yongpan, et al.
Publicado: (2020)

Tanshinone IIA enhances the ovarian reserve and attenuates ovarian oxidative stress in aged mice
por: Bai, Lin, et al.
Publicado: (2022)

Expression and clinical significance of LXRα and SREBP-1c in placentas of preeclampsia
por: Jianhua, Li, et al.
Publicado: (2016)

Metabolism of Tanshinone IIA, Cryptotanshinone and Tanshinone I from Radix Salvia Miltiorrhiza in Zebrafish
por: Wei, Yingjie, et al.
Publicado: (2012)

Antihypertension Induced by Tanshinone IIA Isolated from the Roots of Salvia miltiorrhiza
por: Chan, Paul, et al.
Publicado: (2011)

Tanshinone IIA inhibits cell proliferation and tumor growth by downregulating STAT3 in human gastric cancer
por: Zhang, Yongjun, et al.
Publicado: (2018)

HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells
por: Yen, Jia-Hau, et al.
Publicado: (2018)

Tanshinone IIA: A Promising Natural Cardioprotective Agent
por: Shang, Qinghua, et al.
Publicado: (2012)

Anti-Inflammatory and Immunomodulatory Mechanism of Tanshinone IIA for Atherosclerosis
por: Chen, Zhuo, et al.
Publicado: (2014)

Evaluation of Tanshinone IIA Developmental Toxicity in Zebrafish Embryos
por: Wang, Tao, et al.
Publicado: (2017)

Characterization and Stability of Tanshinone IIA Solid Dispersions with Hydroxyapatite
por: Wang, Xiaopan, et al.
Publicado: (2013)

Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases
por: Guo, Rui, et al.
Publicado: (2020)

Tanshinone IIA: A Review of its Anticancer Effects
por: Fang, Zhong‐ying, et al.
Publicado: (2021)

Renoprotective Effects of Tanshinone IIA: A Literature Review
por: Chen, Zhengtao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qcoevolo738n5ogdpl2iiknven