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Zebrafish mafbb Mutants Display Osteoclast Over-Activation and Bone Deformity Resembling Osteolysis in MCTO Patients

Multicentric carpotarsal osteolysis (MCTO) is a rare skeletal dysplasia with osteolysis at the carpal and tarsal bones. Heterozygous missense mutations in the transcription factor MAFB are found in patients with MCTO. MAFB is reported to negatively regulate osteoclastogenesis in vitro. However, the...

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Detalles Bibliográficos
Autores principales:	Han, Yujie, Shao, Weihao, Zhong, Dan, Ma, Cui, Wei, Xiaona, Ahmed, Abrar, Yu, Tingting, Jing, Wei, Jing, Lili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004647/ https://www.ncbi.nlm.nih.gov/pubmed/33806930 http://dx.doi.org/10.3390/biom11030480

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