Cargando…
Serum BDNF Levels in Acute Stroke: A Systematic Review and Meta-Analysis
Background and objectives: Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins. Low BDNF concentrations have been noted in patients with traditional cardiovascular disease risk factors and have been associated with the increased risk of stroke/transient ischemic attack...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004775/ https://www.ncbi.nlm.nih.gov/pubmed/33809965 http://dx.doi.org/10.3390/medicina57030297 |
_version_ | 1783671980196626432 |
---|---|
author | Karantali, Eleni Kazis, Dimitrios Papavasileiou, Vasileios Prevezianou, Angeliki Chatzikonstantinou, Symela Petridis, Foivos McKenna, Jack Luca, Alina-Costina Trus, Constantin Ciobica, Alin Mavroudis, Ioannis |
author_facet | Karantali, Eleni Kazis, Dimitrios Papavasileiou, Vasileios Prevezianou, Angeliki Chatzikonstantinou, Symela Petridis, Foivos McKenna, Jack Luca, Alina-Costina Trus, Constantin Ciobica, Alin Mavroudis, Ioannis |
author_sort | Karantali, Eleni |
collection | PubMed |
description | Background and objectives: Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins. Low BDNF concentrations have been noted in patients with traditional cardiovascular disease risk factors and have been associated with the increased risk of stroke/transient ischemic attack (TIA). We aimed to study the correlation of BDNF serum levels with acute stroke severity and its potential role as a biomarker in predicting functional outcome. Materials and methods: We systematically searched PubMed, Web of Science, and the Cochrane database using specific keywords. The endpoints examined were the correlation of BDNF with functional outcome, the National Institute of Health stroke scale (NIHSS) measured at the acute phase, and stroke infarct volume. We also compared serum BDNF levels between stroke patients and healthy controls. Results: Twenty-six records were included from the initial 3088 identified. Twenty-five studies reported NIHSS and BDNF levels on the first day after acute stroke. Nine studies were further meta-analyzed. A statistically significant negative correlation between NIHSS and BDNF levels during the acute phase of stroke was noted (COR: −0.3013, 95%CI: (−0.4725; −0.1082), z = −3.01, p = 0.0026). We also noted that BDNF levels were significantly lower in patients with stroke compared to healthy individuals. Due to the heterogeneity of studies, we only conducted a qualitative analysis regarding serum BDNF and functional outcome, while no correlation between BDNF levels and stroke infarct volume was noted. Conclusions: We conclude that in the acute stroke phase, stroke severity is negatively correlated with BDNF levels. Concurrently, patients with acute stroke have significantly lower BDNF levels in serum compared to healthy controls. No correlations between BDNF and stroke infarct volume or functional outcome at follow-up were noted. |
format | Online Article Text |
id | pubmed-8004775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80047752021-03-29 Serum BDNF Levels in Acute Stroke: A Systematic Review and Meta-Analysis Karantali, Eleni Kazis, Dimitrios Papavasileiou, Vasileios Prevezianou, Angeliki Chatzikonstantinou, Symela Petridis, Foivos McKenna, Jack Luca, Alina-Costina Trus, Constantin Ciobica, Alin Mavroudis, Ioannis Medicina (Kaunas) Review Background and objectives: Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins. Low BDNF concentrations have been noted in patients with traditional cardiovascular disease risk factors and have been associated with the increased risk of stroke/transient ischemic attack (TIA). We aimed to study the correlation of BDNF serum levels with acute stroke severity and its potential role as a biomarker in predicting functional outcome. Materials and methods: We systematically searched PubMed, Web of Science, and the Cochrane database using specific keywords. The endpoints examined were the correlation of BDNF with functional outcome, the National Institute of Health stroke scale (NIHSS) measured at the acute phase, and stroke infarct volume. We also compared serum BDNF levels between stroke patients and healthy controls. Results: Twenty-six records were included from the initial 3088 identified. Twenty-five studies reported NIHSS and BDNF levels on the first day after acute stroke. Nine studies were further meta-analyzed. A statistically significant negative correlation between NIHSS and BDNF levels during the acute phase of stroke was noted (COR: −0.3013, 95%CI: (−0.4725; −0.1082), z = −3.01, p = 0.0026). We also noted that BDNF levels were significantly lower in patients with stroke compared to healthy individuals. Due to the heterogeneity of studies, we only conducted a qualitative analysis regarding serum BDNF and functional outcome, while no correlation between BDNF levels and stroke infarct volume was noted. Conclusions: We conclude that in the acute stroke phase, stroke severity is negatively correlated with BDNF levels. Concurrently, patients with acute stroke have significantly lower BDNF levels in serum compared to healthy controls. No correlations between BDNF and stroke infarct volume or functional outcome at follow-up were noted. MDPI 2021-03-22 /pmc/articles/PMC8004775/ /pubmed/33809965 http://dx.doi.org/10.3390/medicina57030297 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Karantali, Eleni Kazis, Dimitrios Papavasileiou, Vasileios Prevezianou, Angeliki Chatzikonstantinou, Symela Petridis, Foivos McKenna, Jack Luca, Alina-Costina Trus, Constantin Ciobica, Alin Mavroudis, Ioannis Serum BDNF Levels in Acute Stroke: A Systematic Review and Meta-Analysis |
title | Serum BDNF Levels in Acute Stroke: A Systematic Review and Meta-Analysis |
title_full | Serum BDNF Levels in Acute Stroke: A Systematic Review and Meta-Analysis |
title_fullStr | Serum BDNF Levels in Acute Stroke: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Serum BDNF Levels in Acute Stroke: A Systematic Review and Meta-Analysis |
title_short | Serum BDNF Levels in Acute Stroke: A Systematic Review and Meta-Analysis |
title_sort | serum bdnf levels in acute stroke: a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004775/ https://www.ncbi.nlm.nih.gov/pubmed/33809965 http://dx.doi.org/10.3390/medicina57030297 |
work_keys_str_mv | AT karantalieleni serumbdnflevelsinacutestrokeasystematicreviewandmetaanalysis AT kazisdimitrios serumbdnflevelsinacutestrokeasystematicreviewandmetaanalysis AT papavasileiouvasileios serumbdnflevelsinacutestrokeasystematicreviewandmetaanalysis AT prevezianouangeliki serumbdnflevelsinacutestrokeasystematicreviewandmetaanalysis AT chatzikonstantinousymela serumbdnflevelsinacutestrokeasystematicreviewandmetaanalysis AT petridisfoivos serumbdnflevelsinacutestrokeasystematicreviewandmetaanalysis AT mckennajack serumbdnflevelsinacutestrokeasystematicreviewandmetaanalysis AT lucaalinacostina serumbdnflevelsinacutestrokeasystematicreviewandmetaanalysis AT trusconstantin serumbdnflevelsinacutestrokeasystematicreviewandmetaanalysis AT ciobicaalin serumbdnflevelsinacutestrokeasystematicreviewandmetaanalysis AT mavroudisioannis serumbdnflevelsinacutestrokeasystematicreviewandmetaanalysis |