Cargando…
Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis
Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize thei...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004782/ https://www.ncbi.nlm.nih.gov/pubmed/33809966 http://dx.doi.org/10.3390/pharmaceutics13030427 |
_version_ | 1783671981822967808 |
---|---|
author | Mirzaaghasi, Amin Han, Yunho Ahn, So-Hee Choi, Chulhee Park, Ji-Ho |
author_facet | Mirzaaghasi, Amin Han, Yunho Ahn, So-Hee Choi, Chulhee Park, Ji-Ho |
author_sort | Mirzaaghasi, Amin |
collection | PubMed |
description | Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize their therapeutic potential as drug delivery vehicles. In this study, we investigated biodistribution and pharmacokinetics of HEK293T cell-derived exosomes and PEGylated liposomes, their synthetic counterparts, into healthy and sepsis mice. We found that biodistribution and pharmacokinetics of exosomes were significantly affected by pathophysiological conditions of sepsis compared to those of liposomes. In the sepsis mice, a substantial number of exosomes were found in the lung after intravenous injection, and their prolonged blood residence was observed due to the liver dysfunction. However, liposomes did not show such sepsis-specific effects significantly. These results demonstrate that exosome-based therapeutics can be developed to manage sepsis and septic shock by virtue of their sepsis-specific in vivo behaviors. |
format | Online Article Text |
id | pubmed-8004782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80047822021-03-29 Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis Mirzaaghasi, Amin Han, Yunho Ahn, So-Hee Choi, Chulhee Park, Ji-Ho Pharmaceutics Article Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize their therapeutic potential as drug delivery vehicles. In this study, we investigated biodistribution and pharmacokinetics of HEK293T cell-derived exosomes and PEGylated liposomes, their synthetic counterparts, into healthy and sepsis mice. We found that biodistribution and pharmacokinetics of exosomes were significantly affected by pathophysiological conditions of sepsis compared to those of liposomes. In the sepsis mice, a substantial number of exosomes were found in the lung after intravenous injection, and their prolonged blood residence was observed due to the liver dysfunction. However, liposomes did not show such sepsis-specific effects significantly. These results demonstrate that exosome-based therapeutics can be developed to manage sepsis and septic shock by virtue of their sepsis-specific in vivo behaviors. MDPI 2021-03-22 /pmc/articles/PMC8004782/ /pubmed/33809966 http://dx.doi.org/10.3390/pharmaceutics13030427 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Mirzaaghasi, Amin Han, Yunho Ahn, So-Hee Choi, Chulhee Park, Ji-Ho Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis |
title | Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis |
title_full | Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis |
title_fullStr | Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis |
title_full_unstemmed | Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis |
title_short | Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis |
title_sort | biodistribution and pharmacokinectics of liposomes and exosomes in a mouse model of sepsis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004782/ https://www.ncbi.nlm.nih.gov/pubmed/33809966 http://dx.doi.org/10.3390/pharmaceutics13030427 |
work_keys_str_mv | AT mirzaaghasiamin biodistributionandpharmacokinecticsofliposomesandexosomesinamousemodelofsepsis AT hanyunho biodistributionandpharmacokinecticsofliposomesandexosomesinamousemodelofsepsis AT ahnsohee biodistributionandpharmacokinecticsofliposomesandexosomesinamousemodelofsepsis AT choichulhee biodistributionandpharmacokinecticsofliposomesandexosomesinamousemodelofsepsis AT parkjiho biodistributionandpharmacokinecticsofliposomesandexosomesinamousemodelofsepsis |