Fenamates as Potential Therapeutics for Neurodegenerative Disorders

Neurodegenerative disorders are desperately lacking treatment options. It is imperative that drug repurposing be considered in the fight against neurodegenerative diseases. Fenamates have been studied for efficacy in treating several neurodegenerative diseases. The purpose of this review is to compr...

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Detalles Bibliográficos
Autores principales: Hill, Jaunetta, Zawia, Nasser H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004804/
https://www.ncbi.nlm.nih.gov/pubmed/33809987
http://dx.doi.org/10.3390/cells10030702
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author Hill, Jaunetta
Zawia, Nasser H.
author_facet Hill, Jaunetta
Zawia, Nasser H.
author_sort Hill, Jaunetta
collection PubMed
description Neurodegenerative disorders are desperately lacking treatment options. It is imperative that drug repurposing be considered in the fight against neurodegenerative diseases. Fenamates have been studied for efficacy in treating several neurodegenerative diseases. The purpose of this review is to comprehensively present the past and current research on fenamates in the context of neurodegenerative diseases with a special emphasis on tolfenamic acid and Alzheimer’s disease. Furthermore, this review discusses the major molecular pathways modulated by fenamates.
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spelling pubmed-80048042021-03-29 Fenamates as Potential Therapeutics for Neurodegenerative Disorders Hill, Jaunetta Zawia, Nasser H. Cells Review Neurodegenerative disorders are desperately lacking treatment options. It is imperative that drug repurposing be considered in the fight against neurodegenerative diseases. Fenamates have been studied for efficacy in treating several neurodegenerative diseases. The purpose of this review is to comprehensively present the past and current research on fenamates in the context of neurodegenerative diseases with a special emphasis on tolfenamic acid and Alzheimer’s disease. Furthermore, this review discusses the major molecular pathways modulated by fenamates. MDPI 2021-03-22 /pmc/articles/PMC8004804/ /pubmed/33809987 http://dx.doi.org/10.3390/cells10030702 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Hill, Jaunetta
Zawia, Nasser H.
Fenamates as Potential Therapeutics for Neurodegenerative Disorders
title Fenamates as Potential Therapeutics for Neurodegenerative Disorders
title_full Fenamates as Potential Therapeutics for Neurodegenerative Disorders
title_fullStr Fenamates as Potential Therapeutics for Neurodegenerative Disorders
title_full_unstemmed Fenamates as Potential Therapeutics for Neurodegenerative Disorders
title_short Fenamates as Potential Therapeutics for Neurodegenerative Disorders
title_sort fenamates as potential therapeutics for neurodegenerative disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004804/
https://www.ncbi.nlm.nih.gov/pubmed/33809987
http://dx.doi.org/10.3390/cells10030702
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