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Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection

The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly worldwide, with more than two million deaths. Evidence indicates the critical role of the vascular endothelium in its pathophysiology but, like potential changes in functional vasodilation, the vascular effect of SARS-CoV-2 at a giv...

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Autores principales: Riou, Marianne, Oulehri, Walid, Momas, Cedric, Rouyer, Olivier, Lebourg, Fabienne, Meyer, Alain, Enache, Irina, Pistea, Cristina, Charloux, Anne, Marcot, Christophe, de Blay, Frederic, Collange, Olivier, Mertes, Michel, Andrès, Emmanuel, Talha, Samy, Geny, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004847/
https://www.ncbi.nlm.nih.gov/pubmed/33806800
http://dx.doi.org/10.3390/jcm10061318
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author Riou, Marianne
Oulehri, Walid
Momas, Cedric
Rouyer, Olivier
Lebourg, Fabienne
Meyer, Alain
Enache, Irina
Pistea, Cristina
Charloux, Anne
Marcot, Christophe
de Blay, Frederic
Collange, Olivier
Mertes, Michel
Andrès, Emmanuel
Talha, Samy
Geny, Bernard
author_facet Riou, Marianne
Oulehri, Walid
Momas, Cedric
Rouyer, Olivier
Lebourg, Fabienne
Meyer, Alain
Enache, Irina
Pistea, Cristina
Charloux, Anne
Marcot, Christophe
de Blay, Frederic
Collange, Olivier
Mertes, Michel
Andrès, Emmanuel
Talha, Samy
Geny, Bernard
author_sort Riou, Marianne
collection PubMed
description The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly worldwide, with more than two million deaths. Evidence indicates the critical role of the vascular endothelium in its pathophysiology but, like potential changes in functional vasodilation, the vascular effect of SARS-CoV-2 at a given distance from the acute infection is largely unknown. We assessed brachial artery flow-mediated dilatation (FMD) in 27 COVID-19 patients needing conventional or intensive care unit hospitalization, three months after SARS-CoV-2 infection diagnosis and in nine age- and sex- matched control subjects. Interestingly, the FMD was lower in COVID-19 patients as compared to controls (8.2 (7.2–8.9) vs. 10.3 (9.1–11.7)); p = 0.002, and half of the hospitalized COVID-19 survivors presented with a reduced FMD < 8% at three months of COVID-19 onset. Impaired FMD was not associated with severe or critical SARS-CoV-2 infection, reflected by ICU hospitalization, total hospitalization duration, or severity of lung damage. In conclusion, reduced FMD is often observed even three months after hospitalization for SARS-CoV-2 infection, but such alteration predominantly appears to not be related to COVID-19 severity. Longer and larger follow-up studies will help to clarify the potential prognosis value of FMD among COVID-19 patients, as well as to further determine the mechanisms involved.
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spelling pubmed-80048472021-03-29 Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection Riou, Marianne Oulehri, Walid Momas, Cedric Rouyer, Olivier Lebourg, Fabienne Meyer, Alain Enache, Irina Pistea, Cristina Charloux, Anne Marcot, Christophe de Blay, Frederic Collange, Olivier Mertes, Michel Andrès, Emmanuel Talha, Samy Geny, Bernard J Clin Med Brief Report The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly worldwide, with more than two million deaths. Evidence indicates the critical role of the vascular endothelium in its pathophysiology but, like potential changes in functional vasodilation, the vascular effect of SARS-CoV-2 at a given distance from the acute infection is largely unknown. We assessed brachial artery flow-mediated dilatation (FMD) in 27 COVID-19 patients needing conventional or intensive care unit hospitalization, three months after SARS-CoV-2 infection diagnosis and in nine age- and sex- matched control subjects. Interestingly, the FMD was lower in COVID-19 patients as compared to controls (8.2 (7.2–8.9) vs. 10.3 (9.1–11.7)); p = 0.002, and half of the hospitalized COVID-19 survivors presented with a reduced FMD < 8% at three months of COVID-19 onset. Impaired FMD was not associated with severe or critical SARS-CoV-2 infection, reflected by ICU hospitalization, total hospitalization duration, or severity of lung damage. In conclusion, reduced FMD is often observed even three months after hospitalization for SARS-CoV-2 infection, but such alteration predominantly appears to not be related to COVID-19 severity. Longer and larger follow-up studies will help to clarify the potential prognosis value of FMD among COVID-19 patients, as well as to further determine the mechanisms involved. MDPI 2021-03-23 /pmc/articles/PMC8004847/ /pubmed/33806800 http://dx.doi.org/10.3390/jcm10061318 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Riou, Marianne
Oulehri, Walid
Momas, Cedric
Rouyer, Olivier
Lebourg, Fabienne
Meyer, Alain
Enache, Irina
Pistea, Cristina
Charloux, Anne
Marcot, Christophe
de Blay, Frederic
Collange, Olivier
Mertes, Michel
Andrès, Emmanuel
Talha, Samy
Geny, Bernard
Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection
title Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection
title_full Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection
title_fullStr Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection
title_full_unstemmed Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection
title_short Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection
title_sort reduced flow-mediated dilatation is not related to covid-19 severity three months after hospitalization for sars-cov-2 infection
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004847/
https://www.ncbi.nlm.nih.gov/pubmed/33806800
http://dx.doi.org/10.3390/jcm10061318
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