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Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases
Matrix metalloproteinase-9 (MMP-9) has been shown to play a key role in endothelial function and perhaps pivotal in the correlation between periodontal disease and cardiovascular disease (CVD). For the study, the impact of MMP-9 of periodontitis and CVD on serum and saliva concentrations was analyze...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004886/ https://www.ncbi.nlm.nih.gov/pubmed/33810003 http://dx.doi.org/10.3390/molecules26061777 |
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author | Isola, Gaetano Polizzi, Alessandro Ronsivalle, Vincenzo Alibrandi, Angela Palazzo, Giuseppe Lo Giudice, Antonino |
author_facet | Isola, Gaetano Polizzi, Alessandro Ronsivalle, Vincenzo Alibrandi, Angela Palazzo, Giuseppe Lo Giudice, Antonino |
author_sort | Isola, Gaetano |
collection | PubMed |
description | Matrix metalloproteinase-9 (MMP-9) has been shown to play a key role in endothelial function and perhaps pivotal in the correlation between periodontal disease and cardiovascular disease (CVD). For the study, the impact of MMP-9 of periodontitis and CVD on serum and saliva concentrations was analyzed. For the study patients with periodontitis (n = 31), CVD (n = 31), periodontitis + CVD (n = 31), and healthy patients (n = 31) were enrolled. Clinical and demographic characteristics as well as serum and salivary MMP-9 were evaluated. MMP-9 concentrations in serum and saliva were statistically elevated in patients with CVD (p < 0.01) and in patients with periodontitis plus CVD (p < 0.001) compared to patients with periodontitis and healthy subjects. Multivariate regression analysis showed that c-reactive protein (hs-CRP) was the only significant predictor for MMP-9 serum (p < 0.001), whereas hs-CRP (p < 0.001) and total cholesterol (p = 0.029) were the statistically significant salivary MMP-9 predictors. This study evidenced that patients with CVD and periodontitis + CVD presented elevated MMP-9 concentrations in serum and saliva compared to patients with periodontitis and healthy subjects. Furthermore, hs-CRP was a negative predictor of serum and salivary MMP-9. |
format | Online Article Text |
id | pubmed-8004886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80048862021-03-29 Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases Isola, Gaetano Polizzi, Alessandro Ronsivalle, Vincenzo Alibrandi, Angela Palazzo, Giuseppe Lo Giudice, Antonino Molecules Article Matrix metalloproteinase-9 (MMP-9) has been shown to play a key role in endothelial function and perhaps pivotal in the correlation between periodontal disease and cardiovascular disease (CVD). For the study, the impact of MMP-9 of periodontitis and CVD on serum and saliva concentrations was analyzed. For the study patients with periodontitis (n = 31), CVD (n = 31), periodontitis + CVD (n = 31), and healthy patients (n = 31) were enrolled. Clinical and demographic characteristics as well as serum and salivary MMP-9 were evaluated. MMP-9 concentrations in serum and saliva were statistically elevated in patients with CVD (p < 0.01) and in patients with periodontitis plus CVD (p < 0.001) compared to patients with periodontitis and healthy subjects. Multivariate regression analysis showed that c-reactive protein (hs-CRP) was the only significant predictor for MMP-9 serum (p < 0.001), whereas hs-CRP (p < 0.001) and total cholesterol (p = 0.029) were the statistically significant salivary MMP-9 predictors. This study evidenced that patients with CVD and periodontitis + CVD presented elevated MMP-9 concentrations in serum and saliva compared to patients with periodontitis and healthy subjects. Furthermore, hs-CRP was a negative predictor of serum and salivary MMP-9. MDPI 2021-03-22 /pmc/articles/PMC8004886/ /pubmed/33810003 http://dx.doi.org/10.3390/molecules26061777 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Isola, Gaetano Polizzi, Alessandro Ronsivalle, Vincenzo Alibrandi, Angela Palazzo, Giuseppe Lo Giudice, Antonino Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases |
title | Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases |
title_full | Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases |
title_fullStr | Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases |
title_full_unstemmed | Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases |
title_short | Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases |
title_sort | impact of matrix metalloproteinase-9 during periodontitis and cardiovascular diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004886/ https://www.ncbi.nlm.nih.gov/pubmed/33810003 http://dx.doi.org/10.3390/molecules26061777 |
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