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Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases

Matrix metalloproteinase-9 (MMP-9) has been shown to play a key role in endothelial function and perhaps pivotal in the correlation between periodontal disease and cardiovascular disease (CVD). For the study, the impact of MMP-9 of periodontitis and CVD on serum and saliva concentrations was analyze...

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Autores principales: Isola, Gaetano, Polizzi, Alessandro, Ronsivalle, Vincenzo, Alibrandi, Angela, Palazzo, Giuseppe, Lo Giudice, Antonino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004886/
https://www.ncbi.nlm.nih.gov/pubmed/33810003
http://dx.doi.org/10.3390/molecules26061777
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author Isola, Gaetano
Polizzi, Alessandro
Ronsivalle, Vincenzo
Alibrandi, Angela
Palazzo, Giuseppe
Lo Giudice, Antonino
author_facet Isola, Gaetano
Polizzi, Alessandro
Ronsivalle, Vincenzo
Alibrandi, Angela
Palazzo, Giuseppe
Lo Giudice, Antonino
author_sort Isola, Gaetano
collection PubMed
description Matrix metalloproteinase-9 (MMP-9) has been shown to play a key role in endothelial function and perhaps pivotal in the correlation between periodontal disease and cardiovascular disease (CVD). For the study, the impact of MMP-9 of periodontitis and CVD on serum and saliva concentrations was analyzed. For the study patients with periodontitis (n = 31), CVD (n = 31), periodontitis + CVD (n = 31), and healthy patients (n = 31) were enrolled. Clinical and demographic characteristics as well as serum and salivary MMP-9 were evaluated. MMP-9 concentrations in serum and saliva were statistically elevated in patients with CVD (p < 0.01) and in patients with periodontitis plus CVD (p < 0.001) compared to patients with periodontitis and healthy subjects. Multivariate regression analysis showed that c-reactive protein (hs-CRP) was the only significant predictor for MMP-9 serum (p < 0.001), whereas hs-CRP (p < 0.001) and total cholesterol (p = 0.029) were the statistically significant salivary MMP-9 predictors. This study evidenced that patients with CVD and periodontitis + CVD presented elevated MMP-9 concentrations in serum and saliva compared to patients with periodontitis and healthy subjects. Furthermore, hs-CRP was a negative predictor of serum and salivary MMP-9.
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spelling pubmed-80048862021-03-29 Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases Isola, Gaetano Polizzi, Alessandro Ronsivalle, Vincenzo Alibrandi, Angela Palazzo, Giuseppe Lo Giudice, Antonino Molecules Article Matrix metalloproteinase-9 (MMP-9) has been shown to play a key role in endothelial function and perhaps pivotal in the correlation between periodontal disease and cardiovascular disease (CVD). For the study, the impact of MMP-9 of periodontitis and CVD on serum and saliva concentrations was analyzed. For the study patients with periodontitis (n = 31), CVD (n = 31), periodontitis + CVD (n = 31), and healthy patients (n = 31) were enrolled. Clinical and demographic characteristics as well as serum and salivary MMP-9 were evaluated. MMP-9 concentrations in serum and saliva were statistically elevated in patients with CVD (p < 0.01) and in patients with periodontitis plus CVD (p < 0.001) compared to patients with periodontitis and healthy subjects. Multivariate regression analysis showed that c-reactive protein (hs-CRP) was the only significant predictor for MMP-9 serum (p < 0.001), whereas hs-CRP (p < 0.001) and total cholesterol (p = 0.029) were the statistically significant salivary MMP-9 predictors. This study evidenced that patients with CVD and periodontitis + CVD presented elevated MMP-9 concentrations in serum and saliva compared to patients with periodontitis and healthy subjects. Furthermore, hs-CRP was a negative predictor of serum and salivary MMP-9. MDPI 2021-03-22 /pmc/articles/PMC8004886/ /pubmed/33810003 http://dx.doi.org/10.3390/molecules26061777 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Isola, Gaetano
Polizzi, Alessandro
Ronsivalle, Vincenzo
Alibrandi, Angela
Palazzo, Giuseppe
Lo Giudice, Antonino
Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases
title Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases
title_full Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases
title_fullStr Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases
title_full_unstemmed Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases
title_short Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases
title_sort impact of matrix metalloproteinase-9 during periodontitis and cardiovascular diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004886/
https://www.ncbi.nlm.nih.gov/pubmed/33810003
http://dx.doi.org/10.3390/molecules26061777
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