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Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15

Arachidonic acid lipoxygenases (ALOXs) have been suggested to function as monomeric enzymes, but more recent data on rabbit ALOX15 indicated that there is a dynamic monomer-dimer equilibrium in aqueous solution. In the presence of an active site ligand (the ALOX15 inhibitor RS7) rabbit ALOX15 was cr...

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Detalles Bibliográficos
Autores principales:	Ivanov, Igor, Cruz, Alejandro, Zhuravlev, Alexander, Di Venere, Almerinda, Nicolai, Eleonora, Stehling, Sabine, Lluch, José M., González-Lafont, Àngels, Kuhn, Hartmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004969/ https://www.ncbi.nlm.nih.gov/pubmed/33807076 http://dx.doi.org/10.3390/ijms22063285

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