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EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson’s Disease
Objective: To evaluate EEG-derived functional connectivity (FC) patterns associated with mild cognitive impairment (MCI) in Parkinson’s disease (PD). METHODS: A sample of 15 patients without cognitive impairment (PD-WCI), 15 with MCI (PD-MCI), and 26 healthy subjects were studied. The EEG was perfor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005012/ https://www.ncbi.nlm.nih.gov/pubmed/33806841 http://dx.doi.org/10.3390/bs11030040 |
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author | Peláez Suárez, Alejandro Armando Berrillo Batista, Sheila Pedroso Ibáñez, Ivonne Casabona Fernández, Enrique Fuentes Campos, Marinet Chacón, Lilia Morales |
author_facet | Peláez Suárez, Alejandro Armando Berrillo Batista, Sheila Pedroso Ibáñez, Ivonne Casabona Fernández, Enrique Fuentes Campos, Marinet Chacón, Lilia Morales |
author_sort | Peláez Suárez, Alejandro Armando |
collection | PubMed |
description | Objective: To evaluate EEG-derived functional connectivity (FC) patterns associated with mild cognitive impairment (MCI) in Parkinson’s disease (PD). METHODS: A sample of 15 patients without cognitive impairment (PD-WCI), 15 with MCI (PD-MCI), and 26 healthy subjects were studied. The EEG was performed in the waking functional state with eyes closed, for the functional analysis it was used the synchronization likelihood (SL) and graph theory (GT). RESULTS: PD-MCI patients showed decreased FC in frequencies alpha, in posterior regions, and delta with a generalized distribution. Patients, compared to the healthy people, presented a decrease in segregation (lower clustering coefficient in alpha p = 0.003 in PD-MCI patients) and increased integration (shorter mean path length in delta (p = 0.004) and theta (p = 0.002) in PD-MCI patients). There were no significant differences in the network topology between the parkinsonian groups. In PD-MCI patients, executive dysfunction correlated positively with global connectivity in beta (r = 0.47) and negatively with the mean path length at beta (r = −0.45); alterations in working memory were negatively correlated with the mean path length at beta r = −0.45. CONCLUSIONS: PD patients present alterations in the FC in all frequencies, those with MCI show less connectivity in the alpha and delta frequencies. The neural networks of the patients show a random topology, with a similar organization between patients with and without MCI. In PD-MCI patients, alterations in executive function and working memory are related to beta integration. |
format | Online Article Text |
id | pubmed-8005012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80050122021-03-29 EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson’s Disease Peláez Suárez, Alejandro Armando Berrillo Batista, Sheila Pedroso Ibáñez, Ivonne Casabona Fernández, Enrique Fuentes Campos, Marinet Chacón, Lilia Morales Behav Sci (Basel) Article Objective: To evaluate EEG-derived functional connectivity (FC) patterns associated with mild cognitive impairment (MCI) in Parkinson’s disease (PD). METHODS: A sample of 15 patients without cognitive impairment (PD-WCI), 15 with MCI (PD-MCI), and 26 healthy subjects were studied. The EEG was performed in the waking functional state with eyes closed, for the functional analysis it was used the synchronization likelihood (SL) and graph theory (GT). RESULTS: PD-MCI patients showed decreased FC in frequencies alpha, in posterior regions, and delta with a generalized distribution. Patients, compared to the healthy people, presented a decrease in segregation (lower clustering coefficient in alpha p = 0.003 in PD-MCI patients) and increased integration (shorter mean path length in delta (p = 0.004) and theta (p = 0.002) in PD-MCI patients). There were no significant differences in the network topology between the parkinsonian groups. In PD-MCI patients, executive dysfunction correlated positively with global connectivity in beta (r = 0.47) and negatively with the mean path length at beta (r = −0.45); alterations in working memory were negatively correlated with the mean path length at beta r = −0.45. CONCLUSIONS: PD patients present alterations in the FC in all frequencies, those with MCI show less connectivity in the alpha and delta frequencies. The neural networks of the patients show a random topology, with a similar organization between patients with and without MCI. In PD-MCI patients, alterations in executive function and working memory are related to beta integration. MDPI 2021-03-23 /pmc/articles/PMC8005012/ /pubmed/33806841 http://dx.doi.org/10.3390/bs11030040 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Peláez Suárez, Alejandro Armando Berrillo Batista, Sheila Pedroso Ibáñez, Ivonne Casabona Fernández, Enrique Fuentes Campos, Marinet Chacón, Lilia Morales EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson’s Disease |
title | EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson’s Disease |
title_full | EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson’s Disease |
title_fullStr | EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson’s Disease |
title_full_unstemmed | EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson’s Disease |
title_short | EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson’s Disease |
title_sort | eeg-derived functional connectivity patterns associated with mild cognitive impairment in parkinson’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005012/ https://www.ncbi.nlm.nih.gov/pubmed/33806841 http://dx.doi.org/10.3390/bs11030040 |
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