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MAFLD in Obese Children: A Challenging Definition

Background: Recently, the new definition of Metabolic (dysfunction) associated fatty liver disease (MAFLD) has gained remarkable scientific interest. We aimed to evaluate the effectiveness of MAFLD definition in selecting obese children at higher cardiovascular risk. Methods: A total of 954 obese ch...

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Autores principales: Di Sessa, Anna, Guarino, Stefano, Umano, Giuseppina Rosaria, Arenella, Mattia, Alfiero, Salvatore, Quaranta, Gaetano, Miraglia del Giudice, Emanuele, Marzuillo, Pierluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005020/
https://www.ncbi.nlm.nih.gov/pubmed/33806784
http://dx.doi.org/10.3390/children8030247
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author Di Sessa, Anna
Guarino, Stefano
Umano, Giuseppina Rosaria
Arenella, Mattia
Alfiero, Salvatore
Quaranta, Gaetano
Miraglia del Giudice, Emanuele
Marzuillo, Pierluigi
author_facet Di Sessa, Anna
Guarino, Stefano
Umano, Giuseppina Rosaria
Arenella, Mattia
Alfiero, Salvatore
Quaranta, Gaetano
Miraglia del Giudice, Emanuele
Marzuillo, Pierluigi
author_sort Di Sessa, Anna
collection PubMed
description Background: Recently, the new definition of Metabolic (dysfunction) associated fatty liver disease (MAFLD) has gained remarkable scientific interest. We aimed to evaluate the effectiveness of MAFLD definition in selecting obese children at higher cardiovascular risk. Methods: A total of 954 obese children and adolescents was retrospectively enrolled. Clinical, biochemical, and metabolic evaluations were performed. Hepatic steatosis was assessed by liver ultrasound. According to the metabolic status, the population was divided in three groups. Group 1 included obese patients without both non-alcoholic fatty liver disease (NAFLD) and metabolic dysregulation; group 2 included patients with obesity and NAFLD (then encompassing one MAFLD criterion); group 3 included patients with obesity, NAFLD and evidence of metabolic dysregulation (then encompassing more than 1 MAFLD criteria). Results: Patients of Group 3 showed a worse cardiometabolic profile, as also proven by the higher percentage of prediabetes (defined as the presence of impaired fasting glucose or impaired glucose tolerance) compared to other groups (p = 0.001). Conclusions: MAFLD criteria in obese children seem to be less accurate in identifying patients having an intrinsic higher cardiometabolic risk. This suggests the need for a more accurate definition in the context of pediatric obesity.
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spelling pubmed-80050202021-03-29 MAFLD in Obese Children: A Challenging Definition Di Sessa, Anna Guarino, Stefano Umano, Giuseppina Rosaria Arenella, Mattia Alfiero, Salvatore Quaranta, Gaetano Miraglia del Giudice, Emanuele Marzuillo, Pierluigi Children (Basel) Communication Background: Recently, the new definition of Metabolic (dysfunction) associated fatty liver disease (MAFLD) has gained remarkable scientific interest. We aimed to evaluate the effectiveness of MAFLD definition in selecting obese children at higher cardiovascular risk. Methods: A total of 954 obese children and adolescents was retrospectively enrolled. Clinical, biochemical, and metabolic evaluations were performed. Hepatic steatosis was assessed by liver ultrasound. According to the metabolic status, the population was divided in three groups. Group 1 included obese patients without both non-alcoholic fatty liver disease (NAFLD) and metabolic dysregulation; group 2 included patients with obesity and NAFLD (then encompassing one MAFLD criterion); group 3 included patients with obesity, NAFLD and evidence of metabolic dysregulation (then encompassing more than 1 MAFLD criteria). Results: Patients of Group 3 showed a worse cardiometabolic profile, as also proven by the higher percentage of prediabetes (defined as the presence of impaired fasting glucose or impaired glucose tolerance) compared to other groups (p = 0.001). Conclusions: MAFLD criteria in obese children seem to be less accurate in identifying patients having an intrinsic higher cardiometabolic risk. This suggests the need for a more accurate definition in the context of pediatric obesity. MDPI 2021-03-23 /pmc/articles/PMC8005020/ /pubmed/33806784 http://dx.doi.org/10.3390/children8030247 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Communication
Di Sessa, Anna
Guarino, Stefano
Umano, Giuseppina Rosaria
Arenella, Mattia
Alfiero, Salvatore
Quaranta, Gaetano
Miraglia del Giudice, Emanuele
Marzuillo, Pierluigi
MAFLD in Obese Children: A Challenging Definition
title MAFLD in Obese Children: A Challenging Definition
title_full MAFLD in Obese Children: A Challenging Definition
title_fullStr MAFLD in Obese Children: A Challenging Definition
title_full_unstemmed MAFLD in Obese Children: A Challenging Definition
title_short MAFLD in Obese Children: A Challenging Definition
title_sort mafld in obese children: a challenging definition
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005020/
https://www.ncbi.nlm.nih.gov/pubmed/33806784
http://dx.doi.org/10.3390/children8030247
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