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MAFLD in Obese Children: A Challenging Definition
Background: Recently, the new definition of Metabolic (dysfunction) associated fatty liver disease (MAFLD) has gained remarkable scientific interest. We aimed to evaluate the effectiveness of MAFLD definition in selecting obese children at higher cardiovascular risk. Methods: A total of 954 obese ch...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005020/ https://www.ncbi.nlm.nih.gov/pubmed/33806784 http://dx.doi.org/10.3390/children8030247 |
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author | Di Sessa, Anna Guarino, Stefano Umano, Giuseppina Rosaria Arenella, Mattia Alfiero, Salvatore Quaranta, Gaetano Miraglia del Giudice, Emanuele Marzuillo, Pierluigi |
author_facet | Di Sessa, Anna Guarino, Stefano Umano, Giuseppina Rosaria Arenella, Mattia Alfiero, Salvatore Quaranta, Gaetano Miraglia del Giudice, Emanuele Marzuillo, Pierluigi |
author_sort | Di Sessa, Anna |
collection | PubMed |
description | Background: Recently, the new definition of Metabolic (dysfunction) associated fatty liver disease (MAFLD) has gained remarkable scientific interest. We aimed to evaluate the effectiveness of MAFLD definition in selecting obese children at higher cardiovascular risk. Methods: A total of 954 obese children and adolescents was retrospectively enrolled. Clinical, biochemical, and metabolic evaluations were performed. Hepatic steatosis was assessed by liver ultrasound. According to the metabolic status, the population was divided in three groups. Group 1 included obese patients without both non-alcoholic fatty liver disease (NAFLD) and metabolic dysregulation; group 2 included patients with obesity and NAFLD (then encompassing one MAFLD criterion); group 3 included patients with obesity, NAFLD and evidence of metabolic dysregulation (then encompassing more than 1 MAFLD criteria). Results: Patients of Group 3 showed a worse cardiometabolic profile, as also proven by the higher percentage of prediabetes (defined as the presence of impaired fasting glucose or impaired glucose tolerance) compared to other groups (p = 0.001). Conclusions: MAFLD criteria in obese children seem to be less accurate in identifying patients having an intrinsic higher cardiometabolic risk. This suggests the need for a more accurate definition in the context of pediatric obesity. |
format | Online Article Text |
id | pubmed-8005020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80050202021-03-29 MAFLD in Obese Children: A Challenging Definition Di Sessa, Anna Guarino, Stefano Umano, Giuseppina Rosaria Arenella, Mattia Alfiero, Salvatore Quaranta, Gaetano Miraglia del Giudice, Emanuele Marzuillo, Pierluigi Children (Basel) Communication Background: Recently, the new definition of Metabolic (dysfunction) associated fatty liver disease (MAFLD) has gained remarkable scientific interest. We aimed to evaluate the effectiveness of MAFLD definition in selecting obese children at higher cardiovascular risk. Methods: A total of 954 obese children and adolescents was retrospectively enrolled. Clinical, biochemical, and metabolic evaluations were performed. Hepatic steatosis was assessed by liver ultrasound. According to the metabolic status, the population was divided in three groups. Group 1 included obese patients without both non-alcoholic fatty liver disease (NAFLD) and metabolic dysregulation; group 2 included patients with obesity and NAFLD (then encompassing one MAFLD criterion); group 3 included patients with obesity, NAFLD and evidence of metabolic dysregulation (then encompassing more than 1 MAFLD criteria). Results: Patients of Group 3 showed a worse cardiometabolic profile, as also proven by the higher percentage of prediabetes (defined as the presence of impaired fasting glucose or impaired glucose tolerance) compared to other groups (p = 0.001). Conclusions: MAFLD criteria in obese children seem to be less accurate in identifying patients having an intrinsic higher cardiometabolic risk. This suggests the need for a more accurate definition in the context of pediatric obesity. MDPI 2021-03-23 /pmc/articles/PMC8005020/ /pubmed/33806784 http://dx.doi.org/10.3390/children8030247 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Communication Di Sessa, Anna Guarino, Stefano Umano, Giuseppina Rosaria Arenella, Mattia Alfiero, Salvatore Quaranta, Gaetano Miraglia del Giudice, Emanuele Marzuillo, Pierluigi MAFLD in Obese Children: A Challenging Definition |
title | MAFLD in Obese Children: A Challenging Definition |
title_full | MAFLD in Obese Children: A Challenging Definition |
title_fullStr | MAFLD in Obese Children: A Challenging Definition |
title_full_unstemmed | MAFLD in Obese Children: A Challenging Definition |
title_short | MAFLD in Obese Children: A Challenging Definition |
title_sort | mafld in obese children: a challenging definition |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005020/ https://www.ncbi.nlm.nih.gov/pubmed/33806784 http://dx.doi.org/10.3390/children8030247 |
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