Cargando…

Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative

Human immunodeficiency virus (HIV) is a life life-threatening and serious infection caused by a virus that attacks [Formula: see text] T-cells, which fight against infections and make a person susceptible to other diseases. It is a global public health problem with no cure; therefore, it is highly i...

Descripción completa

Detalles Bibliográficos
Autores principales: Shah, Zahir, Jan, Rashid, Kumam, Poom, Deebani, Wejdan, Shutaywi, Meshal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005034/
https://www.ncbi.nlm.nih.gov/pubmed/33806939
http://dx.doi.org/10.3390/molecules26061806
_version_ 1783672040890302464
author Shah, Zahir
Jan, Rashid
Kumam, Poom
Deebani, Wejdan
Shutaywi, Meshal
author_facet Shah, Zahir
Jan, Rashid
Kumam, Poom
Deebani, Wejdan
Shutaywi, Meshal
author_sort Shah, Zahir
collection PubMed
description Human immunodeficiency virus (HIV) is a life life-threatening and serious infection caused by a virus that attacks [Formula: see text] T-cells, which fight against infections and make a person susceptible to other diseases. It is a global public health problem with no cure; therefore, it is highly important to study and understand the intricate phenomena of HIV. In this article, we focus on the numerical study of the path-tracking damped oscillatory behavior of a model for the HIV infection of [Formula: see text] T-cells. We formulate fractional dynamics of HIV with a source term for the supply of new CD4(+) T-cells depending on the viral load via the Caputo–Fabrizio derivative. In the formulation of fractional HIV dynamics, we replaced the constant source term for the supply of new [Formula: see text] T-cells from the thymus with a variable source term depending on the concentration of the viral load, and introduced a term that describes the incidence of the HIV infection of [Formula: see text] T-cells. We present a novel numerical scheme for fractional view analysis of the proposed model to highlight the solution pathway of HIV. We inspect the periodic and chaotic behavior of HIV for the given values of input factors using numerical simulations.
format Online
Article
Text
id pubmed-8005034
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80050342021-03-29 Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative Shah, Zahir Jan, Rashid Kumam, Poom Deebani, Wejdan Shutaywi, Meshal Molecules Article Human immunodeficiency virus (HIV) is a life life-threatening and serious infection caused by a virus that attacks [Formula: see text] T-cells, which fight against infections and make a person susceptible to other diseases. It is a global public health problem with no cure; therefore, it is highly important to study and understand the intricate phenomena of HIV. In this article, we focus on the numerical study of the path-tracking damped oscillatory behavior of a model for the HIV infection of [Formula: see text] T-cells. We formulate fractional dynamics of HIV with a source term for the supply of new CD4(+) T-cells depending on the viral load via the Caputo–Fabrizio derivative. In the formulation of fractional HIV dynamics, we replaced the constant source term for the supply of new [Formula: see text] T-cells from the thymus with a variable source term depending on the concentration of the viral load, and introduced a term that describes the incidence of the HIV infection of [Formula: see text] T-cells. We present a novel numerical scheme for fractional view analysis of the proposed model to highlight the solution pathway of HIV. We inspect the periodic and chaotic behavior of HIV for the given values of input factors using numerical simulations. MDPI 2021-03-23 /pmc/articles/PMC8005034/ /pubmed/33806939 http://dx.doi.org/10.3390/molecules26061806 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shah, Zahir
Jan, Rashid
Kumam, Poom
Deebani, Wejdan
Shutaywi, Meshal
Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative
title Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative
title_full Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative
title_fullStr Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative
title_full_unstemmed Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative
title_short Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative
title_sort fractional dynamics of hiv with source term for the supply of new cd4(+) t-cells depending on the viral load via caputo–fabrizio derivative
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005034/
https://www.ncbi.nlm.nih.gov/pubmed/33806939
http://dx.doi.org/10.3390/molecules26061806
work_keys_str_mv AT shahzahir fractionaldynamicsofhivwithsourcetermforthesupplyofnewcd4tcellsdependingontheviralloadviacaputofabrizioderivative
AT janrashid fractionaldynamicsofhivwithsourcetermforthesupplyofnewcd4tcellsdependingontheviralloadviacaputofabrizioderivative
AT kumampoom fractionaldynamicsofhivwithsourcetermforthesupplyofnewcd4tcellsdependingontheviralloadviacaputofabrizioderivative
AT deebaniwejdan fractionaldynamicsofhivwithsourcetermforthesupplyofnewcd4tcellsdependingontheviralloadviacaputofabrizioderivative
AT shutaywimeshal fractionaldynamicsofhivwithsourcetermforthesupplyofnewcd4tcellsdependingontheviralloadviacaputofabrizioderivative