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Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative
Human immunodeficiency virus (HIV) is a life life-threatening and serious infection caused by a virus that attacks [Formula: see text] T-cells, which fight against infections and make a person susceptible to other diseases. It is a global public health problem with no cure; therefore, it is highly i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005034/ https://www.ncbi.nlm.nih.gov/pubmed/33806939 http://dx.doi.org/10.3390/molecules26061806 |
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author | Shah, Zahir Jan, Rashid Kumam, Poom Deebani, Wejdan Shutaywi, Meshal |
author_facet | Shah, Zahir Jan, Rashid Kumam, Poom Deebani, Wejdan Shutaywi, Meshal |
author_sort | Shah, Zahir |
collection | PubMed |
description | Human immunodeficiency virus (HIV) is a life life-threatening and serious infection caused by a virus that attacks [Formula: see text] T-cells, which fight against infections and make a person susceptible to other diseases. It is a global public health problem with no cure; therefore, it is highly important to study and understand the intricate phenomena of HIV. In this article, we focus on the numerical study of the path-tracking damped oscillatory behavior of a model for the HIV infection of [Formula: see text] T-cells. We formulate fractional dynamics of HIV with a source term for the supply of new CD4(+) T-cells depending on the viral load via the Caputo–Fabrizio derivative. In the formulation of fractional HIV dynamics, we replaced the constant source term for the supply of new [Formula: see text] T-cells from the thymus with a variable source term depending on the concentration of the viral load, and introduced a term that describes the incidence of the HIV infection of [Formula: see text] T-cells. We present a novel numerical scheme for fractional view analysis of the proposed model to highlight the solution pathway of HIV. We inspect the periodic and chaotic behavior of HIV for the given values of input factors using numerical simulations. |
format | Online Article Text |
id | pubmed-8005034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80050342021-03-29 Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative Shah, Zahir Jan, Rashid Kumam, Poom Deebani, Wejdan Shutaywi, Meshal Molecules Article Human immunodeficiency virus (HIV) is a life life-threatening and serious infection caused by a virus that attacks [Formula: see text] T-cells, which fight against infections and make a person susceptible to other diseases. It is a global public health problem with no cure; therefore, it is highly important to study and understand the intricate phenomena of HIV. In this article, we focus on the numerical study of the path-tracking damped oscillatory behavior of a model for the HIV infection of [Formula: see text] T-cells. We formulate fractional dynamics of HIV with a source term for the supply of new CD4(+) T-cells depending on the viral load via the Caputo–Fabrizio derivative. In the formulation of fractional HIV dynamics, we replaced the constant source term for the supply of new [Formula: see text] T-cells from the thymus with a variable source term depending on the concentration of the viral load, and introduced a term that describes the incidence of the HIV infection of [Formula: see text] T-cells. We present a novel numerical scheme for fractional view analysis of the proposed model to highlight the solution pathway of HIV. We inspect the periodic and chaotic behavior of HIV for the given values of input factors using numerical simulations. MDPI 2021-03-23 /pmc/articles/PMC8005034/ /pubmed/33806939 http://dx.doi.org/10.3390/molecules26061806 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shah, Zahir Jan, Rashid Kumam, Poom Deebani, Wejdan Shutaywi, Meshal Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative |
title | Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative |
title_full | Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative |
title_fullStr | Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative |
title_full_unstemmed | Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative |
title_short | Fractional Dynamics of HIV with Source Term for the Supply of New CD4(+) T-Cells Depending on the Viral Load via Caputo–Fabrizio Derivative |
title_sort | fractional dynamics of hiv with source term for the supply of new cd4(+) t-cells depending on the viral load via caputo–fabrizio derivative |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005034/ https://www.ncbi.nlm.nih.gov/pubmed/33806939 http://dx.doi.org/10.3390/molecules26061806 |
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