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Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

The self-assembly of tau into paired helical filaments (PHFs) in neurofibrillary tangles (NFTs) is a significant event in Alzheimer’s disease (AD) pathogenesis. Numerous post-translational modifications enhance or inhibit tau assembly into NFTs. Oxidative stress, which accompanies AD, induces multip...

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Detalles Bibliográficos
Autores principales:	Maina, Mahmoud B., Al-Hilaly, Youssra K., Burra, Gunasekhar, Rickard, Janet E., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005035/ https://www.ncbi.nlm.nih.gov/pubmed/33809978 http://dx.doi.org/10.3390/cells10030703

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