Cargando…
Low Seroprevalence of Measles-Specific IgG in Children of Three Ethnic Groups from Mexico: Influence of Age, Sex, Malnutrition and Family Size
Background: The reemergence of measles represents a public health problem. The aim of the study was to determine the seroprevalence of IgG antibodies against measles in children of three ethnic groups in southern Mexico and the nutritional status and demographic risk factors associated. Methods: A c...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005116/ https://www.ncbi.nlm.nih.gov/pubmed/33810023 http://dx.doi.org/10.3390/vaccines9030295 |
_version_ | 1783672059947122688 |
---|---|
author | Sánchez-Alemán, Miguel A. Gutiérrez-Pérez, Ilse A. Díaz-Salgado, Nayeli Zaragoza-García, Oscar Olamendi-Portugal, María Castro-Alarcón, Natividad Parra-Rojas, Isela Guzmán-Guzmán, Iris P. |
author_facet | Sánchez-Alemán, Miguel A. Gutiérrez-Pérez, Ilse A. Díaz-Salgado, Nayeli Zaragoza-García, Oscar Olamendi-Portugal, María Castro-Alarcón, Natividad Parra-Rojas, Isela Guzmán-Guzmán, Iris P. |
author_sort | Sánchez-Alemán, Miguel A. |
collection | PubMed |
description | Background: The reemergence of measles represents a public health problem. The aim of the study was to determine the seroprevalence of IgG antibodies against measles in children of three ethnic groups in southern Mexico and the nutritional status and demographic risk factors associated. Methods: A cross-sectional study in 416 school-age children, 207 belonging to the Tlapaneco ethnic group, 101 to the Mixteco group and 108 were considered Mestizo. Sociodemographic data were collected, an anthropometric evaluation of the children was performed and a fasting blood sample was obtained from each child for the measurement of measles IgG antibodies by Enzyme-Linked Immunosorbent Assay (ELISA). Results: From the total sample, 59% of the children were seropositive for IgG antibodies against measles; in contrast, 41% lacked IgG antibodies. Measles antibody seropositivity was higher in girls (64%). 90.5% of 6-year-old children had higher antibodies seroprevalence, compared to the children between 10 and 13 years old (45.5%). In the three ethnic groups, age was negatively correlated with the index standard ratio (ISR) of measles antibody levels and the families with ≥8 members showed less seropositivity. According to the antibodies levels, most of the positive cases remained around 1 Standard Deviation (SD) of the ISR values and no underweight children had antibody levels above 2 SD. Conclusions: The Anti-Measles serological coverage is low in children of three ethnic groups from Southern Mexico and the age, sex, malnutrition and family size are associated factors. Therefore, it is important to strengthen immunization campaigns, principally in vulnerable groups. |
format | Online Article Text |
id | pubmed-8005116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80051162021-03-29 Low Seroprevalence of Measles-Specific IgG in Children of Three Ethnic Groups from Mexico: Influence of Age, Sex, Malnutrition and Family Size Sánchez-Alemán, Miguel A. Gutiérrez-Pérez, Ilse A. Díaz-Salgado, Nayeli Zaragoza-García, Oscar Olamendi-Portugal, María Castro-Alarcón, Natividad Parra-Rojas, Isela Guzmán-Guzmán, Iris P. Vaccines (Basel) Article Background: The reemergence of measles represents a public health problem. The aim of the study was to determine the seroprevalence of IgG antibodies against measles in children of three ethnic groups in southern Mexico and the nutritional status and demographic risk factors associated. Methods: A cross-sectional study in 416 school-age children, 207 belonging to the Tlapaneco ethnic group, 101 to the Mixteco group and 108 were considered Mestizo. Sociodemographic data were collected, an anthropometric evaluation of the children was performed and a fasting blood sample was obtained from each child for the measurement of measles IgG antibodies by Enzyme-Linked Immunosorbent Assay (ELISA). Results: From the total sample, 59% of the children were seropositive for IgG antibodies against measles; in contrast, 41% lacked IgG antibodies. Measles antibody seropositivity was higher in girls (64%). 90.5% of 6-year-old children had higher antibodies seroprevalence, compared to the children between 10 and 13 years old (45.5%). In the three ethnic groups, age was negatively correlated with the index standard ratio (ISR) of measles antibody levels and the families with ≥8 members showed less seropositivity. According to the antibodies levels, most of the positive cases remained around 1 Standard Deviation (SD) of the ISR values and no underweight children had antibody levels above 2 SD. Conclusions: The Anti-Measles serological coverage is low in children of three ethnic groups from Southern Mexico and the age, sex, malnutrition and family size are associated factors. Therefore, it is important to strengthen immunization campaigns, principally in vulnerable groups. MDPI 2021-03-22 /pmc/articles/PMC8005116/ /pubmed/33810023 http://dx.doi.org/10.3390/vaccines9030295 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Sánchez-Alemán, Miguel A. Gutiérrez-Pérez, Ilse A. Díaz-Salgado, Nayeli Zaragoza-García, Oscar Olamendi-Portugal, María Castro-Alarcón, Natividad Parra-Rojas, Isela Guzmán-Guzmán, Iris P. Low Seroprevalence of Measles-Specific IgG in Children of Three Ethnic Groups from Mexico: Influence of Age, Sex, Malnutrition and Family Size |
title | Low Seroprevalence of Measles-Specific IgG in Children of Three Ethnic Groups from Mexico: Influence of Age, Sex, Malnutrition and Family Size |
title_full | Low Seroprevalence of Measles-Specific IgG in Children of Three Ethnic Groups from Mexico: Influence of Age, Sex, Malnutrition and Family Size |
title_fullStr | Low Seroprevalence of Measles-Specific IgG in Children of Three Ethnic Groups from Mexico: Influence of Age, Sex, Malnutrition and Family Size |
title_full_unstemmed | Low Seroprevalence of Measles-Specific IgG in Children of Three Ethnic Groups from Mexico: Influence of Age, Sex, Malnutrition and Family Size |
title_short | Low Seroprevalence of Measles-Specific IgG in Children of Three Ethnic Groups from Mexico: Influence of Age, Sex, Malnutrition and Family Size |
title_sort | low seroprevalence of measles-specific igg in children of three ethnic groups from mexico: influence of age, sex, malnutrition and family size |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005116/ https://www.ncbi.nlm.nih.gov/pubmed/33810023 http://dx.doi.org/10.3390/vaccines9030295 |
work_keys_str_mv | AT sanchezalemanmiguela lowseroprevalenceofmeaslesspecificigginchildrenofthreeethnicgroupsfrommexicoinfluenceofagesexmalnutritionandfamilysize AT gutierrezperezilsea lowseroprevalenceofmeaslesspecificigginchildrenofthreeethnicgroupsfrommexicoinfluenceofagesexmalnutritionandfamilysize AT diazsalgadonayeli lowseroprevalenceofmeaslesspecificigginchildrenofthreeethnicgroupsfrommexicoinfluenceofagesexmalnutritionandfamilysize AT zaragozagarciaoscar lowseroprevalenceofmeaslesspecificigginchildrenofthreeethnicgroupsfrommexicoinfluenceofagesexmalnutritionandfamilysize AT olamendiportugalmaria lowseroprevalenceofmeaslesspecificigginchildrenofthreeethnicgroupsfrommexicoinfluenceofagesexmalnutritionandfamilysize AT castroalarconnatividad lowseroprevalenceofmeaslesspecificigginchildrenofthreeethnicgroupsfrommexicoinfluenceofagesexmalnutritionandfamilysize AT parrarojasisela lowseroprevalenceofmeaslesspecificigginchildrenofthreeethnicgroupsfrommexicoinfluenceofagesexmalnutritionandfamilysize AT guzmanguzmanirisp lowseroprevalenceofmeaslesspecificigginchildrenofthreeethnicgroupsfrommexicoinfluenceofagesexmalnutritionandfamilysize |