Cargando…

Structural Characterization of Receptor–Receptor Interactions in the Allosteric Modulation of G Protein-Coupled Receptor (GPCR) Dimers

G protein-coupled receptor (GPCR) oligomerization, while contentious, continues to attract the attention of researchers. Numerous experimental investigations have validated the presence of GPCR dimers, and the relevance of dimerization in the effectuation of physiological functions intensifies the a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lazim, Raudah, Suh, Donghyuk, Lee, Jai Woo, Vu, Thi Ngoc Lan, Yoon, Sanghee, Choi, Sun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005122/ https://www.ncbi.nlm.nih.gov/pubmed/33810175 http://dx.doi.org/10.3390/ijms22063241

Ejemplares similares

Multiscale Molecular Modeling in G Protein-Coupled Receptor (GPCR)-Ligand Studies
por: Nakliang, Pratanphorn, et al.
Publicado: (2020)

Expanding the Concept of G Protein-Coupled Receptor (GPCR) Dimer Asymmetry towards GPCR-Interacting Proteins
por: Kamal, Maud, et al.
Publicado: (2011)

Advances in Molecular Dynamics Simulations and Enhanced Sampling Methods for the Study of Protein Systems
por: Lazim, Raudah, et al.
Publicado: (2020)

Allosteric Modulators of G Protein-Coupled Receptors
por: Shpakov, Alexander
Publicado: (2022)

Allosteric modulation of G protein-coupled receptor signaling
por: Shen, Siyuan, et al.
Publicado: (2023)

Allosteric Modulators of Class B G-Protein-Coupled Receptors
por: Hoare, Sam R.J
Publicado: (2007)

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology
por: J Gingell, Joseph, et al.
Publicado: (2016)

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology
por: Gingell, Joseph J, et al.
Publicado: (2016)

Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors
por: Routledge, Sarah J., et al.
Publicado: (2020)

Allosteric modulation in monomers and oligomers of a G protein-coupled receptor
por: Shivnaraine, Rabindra V, et al.
Publicado: (2016)

Analysis of tractable allosteric sites in G protein-coupled receptors
por: Wakefield, Amanda E., et al.
Publicado: (2019)

Allosteric communication between protomers of dopamine Class A GPCR dimers modulates activation
por: Han, Yang, et al.
Publicado: (2009)

Allosteric interactions prime androgen receptor dimerization and activation
por: Wasmuth, Elizabeth V., et al.
Publicado: (2022)

Dimerization with Cannabinoid Receptors Allosterically Modulates Delta Opioid Receptor Activity during Neuropathic Pain
por: Bushlin, Ittai, et al.
Publicado: (2012)

Allosteric Modulation of G Protein Coupled Receptors by Cytoplasmic, Transmembrane and Extracellular Ligands
por: Yanamala, Naveena, et al.
Publicado: (2010)

Cholecystokinin 1 Receptor – A Unique G Protein-Coupled Receptor Activated by Singlet Oxygen (GPCR-ABSO)
por: Jiang, Hong Ning, et al.
Publicado: (2018)

Role of Stoichiometry in the Dimer-Stabilizing Effect of AMPA Receptor Allosteric Modulators
por: Ptak, Christopher P., et al.
Publicado: (2013)

On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System: Focus on Their Role in Pain Modulation
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2013)

Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function
por: Gahbauer, Stefan, et al.
Publicado: (2016)

Investigation of GPCR allosterism and dimerization in single living cells using fluorescent ligands
por: Hill, Stehen
Publicado: (2015)

G protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
por: Hino, Tomoya, et al.
Publicado: (2012)

Dynamical Correlations Reveal Allosteric Sites in G Protein-Coupled Receptors
por: Renault, Pedro, et al.
Publicado: (2020)

Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor
por: Donthamsetti, Prashant, et al.
Publicado: (2021)

The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2014)

Active-State Models of Ternary GPCR Complexes: Determinants of Selective Receptor-G-Protein Coupling
por: Kling, Ralf C., et al.
Publicado: (2013)

GPCR-SAS: A web application for statistical analyses on G protein-coupled receptors sequences
por: Gómez Tamayo, José Carlos, et al.
Publicado: (2018)

In Vitro and In Silico Characterization of G-Protein Coupled Receptor (GPCR) Targets of Phlorofucofuroeckol-A and Dieckol
por: Paudel, Pradeep, et al.
Publicado: (2021)

G protein–coupled receptor interactions with arrestins and GPCR kinases: The unresolved issue of signal bias
por: Chen, Qiuyan, et al.
Publicado: (2022)

Structure of the class D GPCR Ste2 dimer coupled to two G proteins
por: Velazhahan, Vaithish, et al.
Publicado: (2021)

Allosteric Optical Control of a Class B G‐Protein‐Coupled Receptor
por: Broichhagen, Johannes, et al.
Publicado: (2016)

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer
por: Liu, Junke, et al.
Publicado: (2017)

Ligand Docking Methods to Recognize Allosteric Inhibitors for G-Protein-Coupled Receptors
por: Harini, K, et al.
Publicado: (2021)

The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites
por: Hedderich, Janik B., et al.
Publicado: (2022)

Designing allosteric modulators for active conformational state of m-glutamate G-protein coupled receptors
por: Omer, Ankur, et al.
Publicado: (2012)

Combinatorial allosteric modulation of agonist response in a self-interacting G-protein coupled receptor
por: Patrone, Marco, et al.
Publicado: (2020)

Allosteric modulation of G protein‐coupled receptors by amiloride and its derivatives. Perspectives for drug discovery?
por: Massink, Arnault, et al.
Publicado: (2019)

Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor
por: Yen, Hsin-Yung, et al.
Publicado: (2022)

Allosteric Regulation of G-Protein-Coupled Receptors: From Diversity of Molecular Mechanisms to Multiple Allosteric Sites and Their Ligands
por: Shpakov, Alexander O.
Publicado: (2023)

Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer
por: Jacobsen, Stine Engesgaard, et al.
Publicado: (2017)

Assessing the Relative Stability of Dimer Interfaces in G Protein-Coupled Receptors
por: Johnston, Jennifer M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_6k1g4t85felk1ji4nld5c6m2l9