Cargando…

The Influence of Oxidative Stress on Serum Albumin Structure as a Carrier of Selected Diazaphenothiazine with Potential Anticancer Activity

Albumin is one of the most important proteins in human blood. Among its multiple functions, drug binding is crucial in terms of drug distribution in human body. This protein undergoes many modifications that are certain to influence protein activity and affect its structure. One such reaction is alb...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maciążek-Jurczyk, Małgorzata, Morak-Młodawska, Beata, Jeleń, Małgorzata, Kopeć, Wiktoria, Szkudlarek, Agnieszka, Owczarzy, Aleksandra, Kulig, Karolina, Rogóż, Wojciech, Pożycka, Jadwiga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005128/ https://www.ncbi.nlm.nih.gov/pubmed/33806875 http://dx.doi.org/10.3390/ph14030285

Ejemplares similares

Changes in Glycated Human Serum Albumin Binding Affinity for Losartan in the Presence of Fatty Acids In Vitro Spectroscopic Analysis
por: Szkudlarek, Agnieszka, et al.
Publicado: (2022)

Human Serum Albumin Aggregation/Fibrillation and its Abilities to Drugs Binding
por: Maciążek-Jurczyk, Małgorzata, et al.
Publicado: (2020)

The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study
por: Rogóż, Wojciech, et al.
Publicado: (2023)

Spectroscopic Studies of Quinobenzothiazine Derivative in Terms of the In Vitro Interaction with Selected Human Plasma Proteins. Part 1
por: Owczarzy, Aleksandra, et al.
Publicado: (2021)

Comparison of Losartan and Furosemide Interaction with HSA and Their Influence on HSA Antioxidant Potential
por: Rogóż, Wojciech, et al.
Publicado: (2022)

Spectroscopic Analysis of an Antimalarial Drug’s (Quinine) Influence on Human Serum Albumin Reduction and Antioxidant Potential
por: Rogóż, Wojciech, et al.
Publicado: (2022)

Spectroscopic Studies of Quinobenzothiazine Derivative in Terms of the In Vitro Interaction with Selected Human Plasma Proteins: Part 2
por: Owczarzy, Aleksandra, et al.
Publicado: (2023)

Study of Lipophilicity and ADME Properties of 1,9-Diazaphenothiazines with Anticancer Action
por: Morak-Młodawska, Beata, et al.
Publicado: (2023)

Synthesis, Anticancer Activity, and Apoptosis Induction of Novel 3,6-Diazaphenothiazines †
por: Morak-Młodawska, Beata, et al.
Publicado: (2019)

Synthesis, spectroscopic characterization, and anticancer activity of new 10-substituted 1,6-diazaphenothiazines
por: Morak-Młodawska, Beata, et al.
Publicado: (2016)

Influence of Piracetam on Gliclazide—Glycated Human Serum Albumin Interaction. A Spectrofluorometric Study
por: Szkudlarek, Agnieszka, et al.
Publicado: (2018)

Circular Dichroism as a Rapid Method for Analyzing the Binding of a Targeting Ligand to the Surface of Albumin Nanoparticles
por: Kulig, Karolina, et al.
Publicado: (2023)

10-(Prop-2-yn-1-yl)-2,7-diazaphenothiazine
por: Morak-Młodawska, Beata, et al.
Publicado: (2012)

New Synthetic Quinoline (Qui) Derivatives as Novel Antioxidants and Potential HSA’s Antioxidant Activity Modulators—Spectroscopic Studies
por: Rogóż, Wojciech, et al.
Publicado: (2022)

Effect of Temperature on Tolbutamide Binding to Glycated Serum Albumin
por: Szkudlarek, Agnieszka, et al.
Publicado: (2017)

Synthesis and selected immunological properties of 10-substituted 1,8-diazaphenothiazines
por: Morak-Młodawska, Beata, et al.
Publicado: (2014)

In Vitro Investigation of the Interaction of Tolbutamide and Losartan with Human Serum Albumin in Hyperglycemia States
por: Szkudlarek, Agnieszka, et al.
Publicado: (2017)

Design, Synthesis, and Structural Characterization of Novel Diazaphenothiazines with 1,2,3-Triazole Substituents as Promising Antiproliferative Agents
por: Morak-Młodawska, Beata, et al.
Publicado: (2019)

10H-1,9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents
por: Morak-Młodawska, Beata, et al.
Publicado: (2019)

Lipophilicity and Pharmacokinetic Properties of New Anticancer Dipyridothiazine with 1,2,3-Triazole Substituents
por: Morak-Młodawska, Beata, et al.
Publicado: (2022)

Phenothiazines Modified with the Pyridine Ring as Promising Anticancer Agents
por: Morak-Młodawska, Beata, et al.
Publicado: (2021)

In Vitro Investigations of Acetohexamide Binding to Glycated Serum Albumin in the Presence of Fatty Acid
por: Szkudlarek, Agnieszka, et al.
Publicado: (2020)

Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels †
por: Ostróżka-Cieślik, Aneta, et al.
Publicado: (2021)

14-Substituted Diquinothiazines as a New Group of Anticancer Agents
por: Jeleń, Małgorzata, et al.
Publicado: (2023)

Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives—Anticancer and Cholinesterase-Inhibiting Activity
por: Jończyk, Jakub, et al.
Publicado: (2020)

10H-3,6-Diazaphenothiazine induces G(2)/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes
por: Zhang, Jianxin, et al.
Publicado: (2017)

N-[4-(9-Chloroquino[3,2-b]benzo[1,4]thiazin-6-yl)butyl]acetamide
por: Jeleń, Małgorzata, et al.
Publicado: (2012)

Tri- and Pentacyclic Azaphenothiazine as Pro-Apoptotic Agents in Lung Carcinoma with a Protective Potential to Healthy Cell Lines
por: Skonieczna, Magdalena, et al.
Publicado: (2022)

Spectroscopic Studies on the Molecular Ageing of Serum Albumin
por: Chudzik, Mariola, et al.
Publicado: (2016)

6-[3-(p-Tolylsulfonylamino)propyl]diquinothiazine
por: Jeleń, Małgorzata, et al.
Publicado: (2013)

Characteristics of the Protoporphyrin IX Binding Sites on Human Serum Albumin Using Molecular Docking
por: Sułkowski, Leszek, et al.
Publicado: (2016)

The immunosuppressive activities of newly synthesized azaphenothiazines in human and mouse models
por: Zimecki, Michał, et al.
Publicado: (2009)

An Anti-Inflammatory Azaphenothiazine Inhibits Interferon β Expression and CXCL10 Production in KERTr Cells
por: Strzadala, Leon, et al.
Publicado: (2018)

Synthesis of quinoline/naphthalene-containing azaphenothiazines and their potent in vitro antioxidant properties
por: Jeleń, Małgorzata, et al.
Publicado: (2014)

Towards Property Profiling: SYNTHESIS and SAR Probing of New Tetracyclic Diazaphenothiazine Analogues
por: Empel, Anna, et al.
Publicado: (2021)

Synthesis and Structural Characterization of Novel Dimers of Dipyridothiazine as Promising Antiproliferative Agents
por: Martula, Emilia, et al.
Publicado: (2023)

In Vitro Antioxidant and Fibroblast Migration Activities of Fractions Eluded from Dichloromethane Leaf Extract of Marantodes pumilum
por: Balachandran, Abbirami, et al.
Publicado: (2023)

Comparative Studies of Palmatine with Metformin and Glimepiride on the Modulation of Insulin Dependent Signaling Pathway In Vitro, In Vivo & Ex Vivo
por: Nwabueze, Okechukwu Patrick, et al.
Publicado: (2022)

Synthesis, Anti-Breast Cancer Activity, and Molecular Docking Study of a New Group of Acetylenic Quinolinesulfonamide Derivatives
por: Marciniec, Krzysztof, et al.
Publicado: (2017)

The Application of CA and PCA to the Evaluation of Lipophilicity and Physicochemical Properties of Tetracyclic Diazaphenothiazine Derivatives
por: Nycz–Empel, Anna, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kebah3cp9pg24emi67vt4c3dod