Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal Muscle Fiber Atrophy during Simulated Microgravity

Insufficient stress response and elevated oxidative stress can contribute to skeletal muscle atrophy during mechanical unloading (e.g., spaceflight and bedrest). Perturbations in heat shock proteins (e.g., HSP70), antioxidant enzymes, and sarcolemmal neuronal nitric oxidase synthase (nNOS) have been...

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Detalles Bibliográficos
Autores principales: Lawler, John M., Hord, Jeffrey M., Ryan, Pat, Holly, Dylan, Janini Gomes, Mariana, Rodriguez, Dinah, Guzzoni, Vinicius, Garcia-Villatoro, Erika, Green, Chase, Lee, Yang, Little, Sarah, Garcia, Marcela, Hill, Lorrie, Brooks, Mary-Catherine, Lawler, Matthew S., Keys, Nicolette, Mohajeri, Amin, Kamal, Khaled Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005132/
https://www.ncbi.nlm.nih.gov/pubmed/33806917
http://dx.doi.org/10.3390/ijms22063252

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