Epithelial Mutant p53 Promotes Resistance to Anti-PD-1-Mediated Oral Cancer Immunoprevention in Carcinogen-Induced Mouse Models

SIMPLE SUMMARY: Immune checkpoint blockade with anti-PD-1 antibodies blocks the development of oral squamous cell carcinomas (OSCCs) in preclinical models. Understanding whether the genetic alterations that accumulate during oral cancer development affect the response to PD-1 inhibitors is critical...

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Detalles Bibliográficos
Autores principales: Wang, Jin, Hu, Yuan, Escamilla-Rivera, Vicente, Gonzalez, Cassandra L., Tang, Lin, Wang, Bingbing, El-Naggar, Adel K., Myers, Jeffrey N., Caulin, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005156/
https://www.ncbi.nlm.nih.gov/pubmed/33806894
http://dx.doi.org/10.3390/cancers13061471

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