The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration

Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide variety of innate and adaptive immune cells orchestrate the complex process of muscle repair. This review provides information about the various types of immune cells and biomolecules that have been shown to mediat...

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Autores principales: Ziemkiewicz, Natalia, Hilliard, Genevieve, Pullen, Nicholas A., Garg, Koyal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005179/
https://www.ncbi.nlm.nih.gov/pubmed/33806895
http://dx.doi.org/10.3390/ijms22063265
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author Ziemkiewicz, Natalia
Hilliard, Genevieve
Pullen, Nicholas A.
Garg, Koyal
author_facet Ziemkiewicz, Natalia
Hilliard, Genevieve
Pullen, Nicholas A.
Garg, Koyal
author_sort Ziemkiewicz, Natalia
collection PubMed
description Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide variety of innate and adaptive immune cells orchestrate the complex process of muscle repair. This review provides information about the various types of immune cells and biomolecules that have been shown to mediate muscle regeneration following injury and degenerative diseases. Recently developed cell and drug-based immunomodulatory strategies are highlighted. An improved understanding of the immune response to injured and diseased skeletal muscle will be essential for the development of therapeutic strategies.
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spelling pubmed-80051792021-03-29 The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration Ziemkiewicz, Natalia Hilliard, Genevieve Pullen, Nicholas A. Garg, Koyal Int J Mol Sci Review Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide variety of innate and adaptive immune cells orchestrate the complex process of muscle repair. This review provides information about the various types of immune cells and biomolecules that have been shown to mediate muscle regeneration following injury and degenerative diseases. Recently developed cell and drug-based immunomodulatory strategies are highlighted. An improved understanding of the immune response to injured and diseased skeletal muscle will be essential for the development of therapeutic strategies. MDPI 2021-03-23 /pmc/articles/PMC8005179/ /pubmed/33806895 http://dx.doi.org/10.3390/ijms22063265 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ziemkiewicz, Natalia
Hilliard, Genevieve
Pullen, Nicholas A.
Garg, Koyal
The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration
title The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration
title_full The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration
title_fullStr The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration
title_full_unstemmed The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration
title_short The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration
title_sort role of innate and adaptive immune cells in skeletal muscle regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005179/
https://www.ncbi.nlm.nih.gov/pubmed/33806895
http://dx.doi.org/10.3390/ijms22063265
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