Tenofovir Alafenamide Rescues Renal Tubules in Patients with Chronic Hepatitis B

Nucles(t)ide analogs (NAs) are effective for chronic hepatitis B (CHB). NAs suppress hepatic decompensation and hepatocarcinogenesis, leading to a dramatic improvement of the natural course of patients with CHB. However, renal dysfunction is becoming an important issue for the management of CHB. Ren...

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Autores principales: Sano, Tomoya, Kawaguchi, Takumi, Ide, Tatsuya, Amano, Keisuke, Kuwahara, Reiichiro, Arinaga-Hino, Teruko, Torimura, Takuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005189/
https://www.ncbi.nlm.nih.gov/pubmed/33806752
http://dx.doi.org/10.3390/life11030263
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author Sano, Tomoya
Kawaguchi, Takumi
Ide, Tatsuya
Amano, Keisuke
Kuwahara, Reiichiro
Arinaga-Hino, Teruko
Torimura, Takuji
author_facet Sano, Tomoya
Kawaguchi, Takumi
Ide, Tatsuya
Amano, Keisuke
Kuwahara, Reiichiro
Arinaga-Hino, Teruko
Torimura, Takuji
author_sort Sano, Tomoya
collection PubMed
description Nucles(t)ide analogs (NAs) are effective for chronic hepatitis B (CHB). NAs suppress hepatic decompensation and hepatocarcinogenesis, leading to a dramatic improvement of the natural course of patients with CHB. However, renal dysfunction is becoming an important issue for the management of CHB. Renal dysfunction develops in patients with the long-term treatment of NAs including adefovir dipivoxil and tenofovir disoproxil fumarate. Recently, several studies have reported that the newly approved tenofovir alafenamide (TAF) has a safe profile for the kidney due to greater plasma stability. In this mini-review, we discuss the effectiveness of switching to TAF for NAs-related renal tubular dysfunction in patients with CHB.
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spelling pubmed-80051892021-03-29 Tenofovir Alafenamide Rescues Renal Tubules in Patients with Chronic Hepatitis B Sano, Tomoya Kawaguchi, Takumi Ide, Tatsuya Amano, Keisuke Kuwahara, Reiichiro Arinaga-Hino, Teruko Torimura, Takuji Life (Basel) Communication Nucles(t)ide analogs (NAs) are effective for chronic hepatitis B (CHB). NAs suppress hepatic decompensation and hepatocarcinogenesis, leading to a dramatic improvement of the natural course of patients with CHB. However, renal dysfunction is becoming an important issue for the management of CHB. Renal dysfunction develops in patients with the long-term treatment of NAs including adefovir dipivoxil and tenofovir disoproxil fumarate. Recently, several studies have reported that the newly approved tenofovir alafenamide (TAF) has a safe profile for the kidney due to greater plasma stability. In this mini-review, we discuss the effectiveness of switching to TAF for NAs-related renal tubular dysfunction in patients with CHB. MDPI 2021-03-23 /pmc/articles/PMC8005189/ /pubmed/33806752 http://dx.doi.org/10.3390/life11030263 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Communication
Sano, Tomoya
Kawaguchi, Takumi
Ide, Tatsuya
Amano, Keisuke
Kuwahara, Reiichiro
Arinaga-Hino, Teruko
Torimura, Takuji
Tenofovir Alafenamide Rescues Renal Tubules in Patients with Chronic Hepatitis B
title Tenofovir Alafenamide Rescues Renal Tubules in Patients with Chronic Hepatitis B
title_full Tenofovir Alafenamide Rescues Renal Tubules in Patients with Chronic Hepatitis B
title_fullStr Tenofovir Alafenamide Rescues Renal Tubules in Patients with Chronic Hepatitis B
title_full_unstemmed Tenofovir Alafenamide Rescues Renal Tubules in Patients with Chronic Hepatitis B
title_short Tenofovir Alafenamide Rescues Renal Tubules in Patients with Chronic Hepatitis B
title_sort tenofovir alafenamide rescues renal tubules in patients with chronic hepatitis b
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005189/
https://www.ncbi.nlm.nih.gov/pubmed/33806752
http://dx.doi.org/10.3390/life11030263
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