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Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells
BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic beta cells. Interferon-α (IFNα), an antiviral cytokine, is expressed in the pancreatic islets in early T1D, which may be secondary to viral infections. However, not all patients harb...
Autores principales: | Coomans de Brachène, Alexandra, Castela, Angela, Musuaya, Anyïshai E., Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005246/ https://www.ncbi.nlm.nih.gov/pubmed/33773604 http://dx.doi.org/10.1186/s13317-021-00148-2 |
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