Research progress on coronavirus S proteins and their receptors

Coronaviruses are a large family of important pathogens that cause human and animal diseases. At the end of 2019, a pneumonia epidemic caused by a novel coronavirus brought attention to coronaviruses. Exploring the interaction between the virus and its receptor will be helpful in developing preventi...

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Detalles Bibliográficos
Autores principales: Yuan, Hao-Wen, Wen, Hong-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005323/
https://www.ncbi.nlm.nih.gov/pubmed/33778918
http://dx.doi.org/10.1007/s00705-021-05008-y
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author Yuan, Hao-Wen
Wen, Hong-Ling
author_facet Yuan, Hao-Wen
Wen, Hong-Ling
author_sort Yuan, Hao-Wen
collection PubMed
description Coronaviruses are a large family of important pathogens that cause human and animal diseases. At the end of 2019, a pneumonia epidemic caused by a novel coronavirus brought attention to coronaviruses. Exploring the interaction between the virus and its receptor will be helpful in developing preventive vaccines and therapeutic drugs. The coronavirus spike protein (S) plays an important role in both binding to receptors on host cells and fusion of the viral membrane with the host cell membrane. This review introduces the structure and function of the S protein and its receptor, focusing on the binding mode and binding region of both.
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spelling pubmed-80053232021-03-29 Research progress on coronavirus S proteins and their receptors Yuan, Hao-Wen Wen, Hong-Ling Arch Virol Review Coronaviruses are a large family of important pathogens that cause human and animal diseases. At the end of 2019, a pneumonia epidemic caused by a novel coronavirus brought attention to coronaviruses. Exploring the interaction between the virus and its receptor will be helpful in developing preventive vaccines and therapeutic drugs. The coronavirus spike protein (S) plays an important role in both binding to receptors on host cells and fusion of the viral membrane with the host cell membrane. This review introduces the structure and function of the S protein and its receptor, focusing on the binding mode and binding region of both. Springer Vienna 2021-03-28 2021 /pmc/articles/PMC8005323/ /pubmed/33778918 http://dx.doi.org/10.1007/s00705-021-05008-y Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH, AT part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Yuan, Hao-Wen
Wen, Hong-Ling
Research progress on coronavirus S proteins and their receptors
title Research progress on coronavirus S proteins and their receptors
title_full Research progress on coronavirus S proteins and their receptors
title_fullStr Research progress on coronavirus S proteins and their receptors
title_full_unstemmed Research progress on coronavirus S proteins and their receptors
title_short Research progress on coronavirus S proteins and their receptors
title_sort research progress on coronavirus s proteins and their receptors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005323/
https://www.ncbi.nlm.nih.gov/pubmed/33778918
http://dx.doi.org/10.1007/s00705-021-05008-y
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