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Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis

BACKGROUND: The novel coronavirus disease 2019 (COVID-19) has spread worldwide since the beginning of 2020, placing the heavy burden on the health systems all over the world. The population that particularly has been affected by the pandemic is the group of patients suffering from diabetes mellitus....

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Autores principales: Kaminska, Halla, Szarpak, Lukasz, Kosior, Dariusz, Wieczorek, Wojciech, Szarpak, Agnieszka, Al-Jeabory, Mahdi, Gawel, Wladyslaw, Gasecka, Aleksandra, Jaguszewski, Milosz J., Jarosz-Chobot, Przemyslawa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005367/
https://www.ncbi.nlm.nih.gov/pubmed/33778910
http://dx.doi.org/10.1007/s00592-021-01701-1
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author Kaminska, Halla
Szarpak, Lukasz
Kosior, Dariusz
Wieczorek, Wojciech
Szarpak, Agnieszka
Al-Jeabory, Mahdi
Gawel, Wladyslaw
Gasecka, Aleksandra
Jaguszewski, Milosz J.
Jarosz-Chobot, Przemyslawa
author_facet Kaminska, Halla
Szarpak, Lukasz
Kosior, Dariusz
Wieczorek, Wojciech
Szarpak, Agnieszka
Al-Jeabory, Mahdi
Gawel, Wladyslaw
Gasecka, Aleksandra
Jaguszewski, Milosz J.
Jarosz-Chobot, Przemyslawa
author_sort Kaminska, Halla
collection PubMed
description BACKGROUND: The novel coronavirus disease 2019 (COVID-19) has spread worldwide since the beginning of 2020, placing the heavy burden on the health systems all over the world. The population that particularly has been affected by the pandemic is the group of patients suffering from diabetes mellitus. Having taken the public health in considerations, we have decided to perform a systematic review and meta-analysis of diabetes mellitus on in-hospital mortality in patients with COVID-19. METHODS: A systematic literature review (MEDLINE, EMBASE, Web of Science, Scopus, Cochrane) including all published clinical trials or observational studies published till December 10, 2020, was performed using following terms “diabetes mellitus” OR “diabetes” OR “DM” AND “survival” OR “mortality” AND “SARS-CoV-2” OR “COVID-19”. RESULTS: Nineteen studies were included out of the 7327 initially identified studies. Mortality of DM patients vs non-DM patients was 21.3 versus 6.1%, respectively (OR = 2.39; 95%CI: 1.65, 3.64; P < 0.001), while severe disease in DM and non-DM group varied and amounted to 34.8% versus 22.8% (OR = 1.43; 95%CI: 0.82, 2.50; P = 0.20). In the DM group, the complications were observed far more often when compared with non-DM group, both in acute respiratory distress (31.4 vs. 17.2%; OR = 2.38; 95%CI:1.80, 3.13; P < 0.001), acute cardiac injury (22.0% vs. 12.8%; OR = 2.59; 95%CI: 1.81, 3.73; P < 0.001), and acute kidney injury (19.1 vs. 10.2%; OR = 1.97; 95%CI: 1.36, 2.85; P < 0.001). CONCLUSIONS: Based on the findings, we shall conclude that diabetes is an independent risk factor of the severity of COVID-19 in-hospital settings; therefore, patients with diabetes shall aim to reduce the exposure to the potential infection of COVID-19. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00592-021-01701-1.
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spelling pubmed-80053672021-03-29 Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis Kaminska, Halla Szarpak, Lukasz Kosior, Dariusz Wieczorek, Wojciech Szarpak, Agnieszka Al-Jeabory, Mahdi Gawel, Wladyslaw Gasecka, Aleksandra Jaguszewski, Milosz J. Jarosz-Chobot, Przemyslawa Acta Diabetol Original Article BACKGROUND: The novel coronavirus disease 2019 (COVID-19) has spread worldwide since the beginning of 2020, placing the heavy burden on the health systems all over the world. The population that particularly has been affected by the pandemic is the group of patients suffering from diabetes mellitus. Having taken the public health in considerations, we have decided to perform a systematic review and meta-analysis of diabetes mellitus on in-hospital mortality in patients with COVID-19. METHODS: A systematic literature review (MEDLINE, EMBASE, Web of Science, Scopus, Cochrane) including all published clinical trials or observational studies published till December 10, 2020, was performed using following terms “diabetes mellitus” OR “diabetes” OR “DM” AND “survival” OR “mortality” AND “SARS-CoV-2” OR “COVID-19”. RESULTS: Nineteen studies were included out of the 7327 initially identified studies. Mortality of DM patients vs non-DM patients was 21.3 versus 6.1%, respectively (OR = 2.39; 95%CI: 1.65, 3.64; P < 0.001), while severe disease in DM and non-DM group varied and amounted to 34.8% versus 22.8% (OR = 1.43; 95%CI: 0.82, 2.50; P = 0.20). In the DM group, the complications were observed far more often when compared with non-DM group, both in acute respiratory distress (31.4 vs. 17.2%; OR = 2.38; 95%CI:1.80, 3.13; P < 0.001), acute cardiac injury (22.0% vs. 12.8%; OR = 2.59; 95%CI: 1.81, 3.73; P < 0.001), and acute kidney injury (19.1 vs. 10.2%; OR = 1.97; 95%CI: 1.36, 2.85; P < 0.001). CONCLUSIONS: Based on the findings, we shall conclude that diabetes is an independent risk factor of the severity of COVID-19 in-hospital settings; therefore, patients with diabetes shall aim to reduce the exposure to the potential infection of COVID-19. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00592-021-01701-1. Springer Milan 2021-03-20 2021 /pmc/articles/PMC8005367/ /pubmed/33778910 http://dx.doi.org/10.1007/s00592-021-01701-1 Text en © Springer-Verlag Italia S.r.l., part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Kaminska, Halla
Szarpak, Lukasz
Kosior, Dariusz
Wieczorek, Wojciech
Szarpak, Agnieszka
Al-Jeabory, Mahdi
Gawel, Wladyslaw
Gasecka, Aleksandra
Jaguszewski, Milosz J.
Jarosz-Chobot, Przemyslawa
Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis
title Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis
title_full Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis
title_fullStr Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis
title_full_unstemmed Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis
title_short Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis
title_sort impact of diabetes mellitus on in-hospital mortality in adult patients with covid-19: a systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005367/
https://www.ncbi.nlm.nih.gov/pubmed/33778910
http://dx.doi.org/10.1007/s00592-021-01701-1
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