Human MUS81: A Fence-Sitter in Cancer

MUS81 complex, exhibiting endonuclease activity on specific DNA structures, plays an influential part in DNA repair. Research has proved that MUS81 is dispensable for embryonic development and cell viability in mammals. However, an intricate picture has emerged from studies in which discrepant gene...

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Autores principales: Chen, Sisi, Geng, Xinwei, Syeda, Madiha Zahra, Huang, Zhengming, Zhang, Chao, Ying, Songmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005573/
https://www.ncbi.nlm.nih.gov/pubmed/33791310
http://dx.doi.org/10.3389/fcell.2021.657305
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author Chen, Sisi
Geng, Xinwei
Syeda, Madiha Zahra
Huang, Zhengming
Zhang, Chao
Ying, Songmin
author_facet Chen, Sisi
Geng, Xinwei
Syeda, Madiha Zahra
Huang, Zhengming
Zhang, Chao
Ying, Songmin
author_sort Chen, Sisi
collection PubMed
description MUS81 complex, exhibiting endonuclease activity on specific DNA structures, plays an influential part in DNA repair. Research has proved that MUS81 is dispensable for embryonic development and cell viability in mammals. However, an intricate picture has emerged from studies in which discrepant gene mutations completely alter the role of MUS81 in human cancers. Here, we review the recent understanding of how MUS81 functions in tumors with distinct genetic backgrounds and discuss the potential therapeutic strategies targeting MUS81 in cancer.
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spelling pubmed-80055732021-03-30 Human MUS81: A Fence-Sitter in Cancer Chen, Sisi Geng, Xinwei Syeda, Madiha Zahra Huang, Zhengming Zhang, Chao Ying, Songmin Front Cell Dev Biol Cell and Developmental Biology MUS81 complex, exhibiting endonuclease activity on specific DNA structures, plays an influential part in DNA repair. Research has proved that MUS81 is dispensable for embryonic development and cell viability in mammals. However, an intricate picture has emerged from studies in which discrepant gene mutations completely alter the role of MUS81 in human cancers. Here, we review the recent understanding of how MUS81 functions in tumors with distinct genetic backgrounds and discuss the potential therapeutic strategies targeting MUS81 in cancer. Frontiers Media S.A. 2021-03-15 /pmc/articles/PMC8005573/ /pubmed/33791310 http://dx.doi.org/10.3389/fcell.2021.657305 Text en Copyright © 2021 Chen, Geng, Syeda, Huang, Zhang and Ying. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chen, Sisi
Geng, Xinwei
Syeda, Madiha Zahra
Huang, Zhengming
Zhang, Chao
Ying, Songmin
Human MUS81: A Fence-Sitter in Cancer
title Human MUS81: A Fence-Sitter in Cancer
title_full Human MUS81: A Fence-Sitter in Cancer
title_fullStr Human MUS81: A Fence-Sitter in Cancer
title_full_unstemmed Human MUS81: A Fence-Sitter in Cancer
title_short Human MUS81: A Fence-Sitter in Cancer
title_sort human mus81: a fence-sitter in cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005573/
https://www.ncbi.nlm.nih.gov/pubmed/33791310
http://dx.doi.org/10.3389/fcell.2021.657305
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AT syedamadihazahra humanmus81afencesitterincancer
AT huangzhengming humanmus81afencesitterincancer
AT zhangchao humanmus81afencesitterincancer
AT yingsongmin humanmus81afencesitterincancer

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