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Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years
Acute kidney injury (AKI) in the pediatric intensive care unit (PICU) is an important risk factor for increased morbidity and mortality during hospitalization. Over the past decade, accumulated data on children and young people indicates that acute episodes of kidney dysfunction can have lasting con...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005629/ https://www.ncbi.nlm.nih.gov/pubmed/33791260 http://dx.doi.org/10.3389/fped.2021.648587 |
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author | Hessey, Erin Melhem, Nabil Alobaidi, Rashid Ulrich, Emma Morgan, Catherine Bagshaw, Sean M. Sinha, Manish D. |
author_facet | Hessey, Erin Melhem, Nabil Alobaidi, Rashid Ulrich, Emma Morgan, Catherine Bagshaw, Sean M. Sinha, Manish D. |
author_sort | Hessey, Erin |
collection | PubMed |
description | Acute kidney injury (AKI) in the pediatric intensive care unit (PICU) is an important risk factor for increased morbidity and mortality during hospitalization. Over the past decade, accumulated data on children and young people indicates that acute episodes of kidney dysfunction can have lasting consequences on multiple organ systems and health outcomes. To date, there are no guidelines for follow-up of surviving children that may be at risk of long-term sequelae following AKI in the PICU. This narrative review aims to describe literature from the last 5 years on the risk of medium and long-term kidney and non-kidney outcomes after AKI in the PICU. More specifically, we will focus on outcomes in children and young people following AKI in the general PICU population and children undergoing cardiac surgery. These outcomes include mortality, hypertension, proteinuria, chronic kidney disease, and healthcare utilization. We also aim to highlight current gaps in knowledge in medium and long-term outcomes in this pediatric population. We suggest a framework for future research to develop evidence-based guidelines for follow-up of children surviving an episode of critical illness and AKI. |
format | Online Article Text |
id | pubmed-8005629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80056292021-03-30 Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years Hessey, Erin Melhem, Nabil Alobaidi, Rashid Ulrich, Emma Morgan, Catherine Bagshaw, Sean M. Sinha, Manish D. Front Pediatr Pediatrics Acute kidney injury (AKI) in the pediatric intensive care unit (PICU) is an important risk factor for increased morbidity and mortality during hospitalization. Over the past decade, accumulated data on children and young people indicates that acute episodes of kidney dysfunction can have lasting consequences on multiple organ systems and health outcomes. To date, there are no guidelines for follow-up of surviving children that may be at risk of long-term sequelae following AKI in the PICU. This narrative review aims to describe literature from the last 5 years on the risk of medium and long-term kidney and non-kidney outcomes after AKI in the PICU. More specifically, we will focus on outcomes in children and young people following AKI in the general PICU population and children undergoing cardiac surgery. These outcomes include mortality, hypertension, proteinuria, chronic kidney disease, and healthcare utilization. We also aim to highlight current gaps in knowledge in medium and long-term outcomes in this pediatric population. We suggest a framework for future research to develop evidence-based guidelines for follow-up of children surviving an episode of critical illness and AKI. Frontiers Media S.A. 2021-03-15 /pmc/articles/PMC8005629/ /pubmed/33791260 http://dx.doi.org/10.3389/fped.2021.648587 Text en Copyright © 2021 Hessey, Melhem, Alobaidi, Ulrich, Morgan, Bagshaw and Sinha. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Hessey, Erin Melhem, Nabil Alobaidi, Rashid Ulrich, Emma Morgan, Catherine Bagshaw, Sean M. Sinha, Manish D. Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years |
title | Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years |
title_full | Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years |
title_fullStr | Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years |
title_full_unstemmed | Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years |
title_short | Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years |
title_sort | acute kidney injury in critically ill children is not all acute: lessons over the last 5 years |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005629/ https://www.ncbi.nlm.nih.gov/pubmed/33791260 http://dx.doi.org/10.3389/fped.2021.648587 |
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