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Gut Microbiome Alterations in Patients With Thyroid Nodules

Thyroid nodules are found in nearly half of the adult population. Accumulating evidence suggests that the gut microbiota plays an important role in thyroid metabolism, yet the association between gut microbiota capacity, thyroid nodules, and thyroid function has not been studied comprehensively. We...

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Autores principales: Li, Ang, Li, Tiantian, Gao, Xinxin, Yan, Hang, Chen, Jingfeng, Huang, Meng, Wang, Lin, Yin, Detao, Li, Hongqiang, Ma, Runsheng, Zeng, Qiang, Ding, Suying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005713/
https://www.ncbi.nlm.nih.gov/pubmed/33791245
http://dx.doi.org/10.3389/fcimb.2021.643968
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author Li, Ang
Li, Tiantian
Gao, Xinxin
Yan, Hang
Chen, Jingfeng
Huang, Meng
Wang, Lin
Yin, Detao
Li, Hongqiang
Ma, Runsheng
Zeng, Qiang
Ding, Suying
author_facet Li, Ang
Li, Tiantian
Gao, Xinxin
Yan, Hang
Chen, Jingfeng
Huang, Meng
Wang, Lin
Yin, Detao
Li, Hongqiang
Ma, Runsheng
Zeng, Qiang
Ding, Suying
author_sort Li, Ang
collection PubMed
description Thyroid nodules are found in nearly half of the adult population. Accumulating evidence suggests that the gut microbiota plays an important role in thyroid metabolism, yet the association between gut microbiota capacity, thyroid nodules, and thyroid function has not been studied comprehensively. We performed a gut microbiome genome-wide association study in 196 patients with thyroid nodules and 283 controls by using whole-genome shotgun sequencing. We found that participants with high-grade thyroid nodules have decreased number of gut microbial species and gene families compared with those with lower grade nodules and controls. There are also significant alterations in the overall microbial composition in participants with high-grade thyroid nodules. The gut microbiome in participants with high-grade thyroid nodules is characterized by greater amino acid degradation and lower butyrate production. The relative abundances of multiple butyrate producing microbes are reduced in patients with high-grade thyroid nodules and the relative abundances of L-histidine metabolism pathways are associated with thyrotropin-releasing hormone. Our study describes the gut microbiome characteristics in thyroid nodules and a gut-thyroid link and highlight specific gut microbiota as a potential therapeutic target to regulate thyroid metabolism.
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spelling pubmed-80057132021-03-30 Gut Microbiome Alterations in Patients With Thyroid Nodules Li, Ang Li, Tiantian Gao, Xinxin Yan, Hang Chen, Jingfeng Huang, Meng Wang, Lin Yin, Detao Li, Hongqiang Ma, Runsheng Zeng, Qiang Ding, Suying Front Cell Infect Microbiol Cellular and Infection Microbiology Thyroid nodules are found in nearly half of the adult population. Accumulating evidence suggests that the gut microbiota plays an important role in thyroid metabolism, yet the association between gut microbiota capacity, thyroid nodules, and thyroid function has not been studied comprehensively. We performed a gut microbiome genome-wide association study in 196 patients with thyroid nodules and 283 controls by using whole-genome shotgun sequencing. We found that participants with high-grade thyroid nodules have decreased number of gut microbial species and gene families compared with those with lower grade nodules and controls. There are also significant alterations in the overall microbial composition in participants with high-grade thyroid nodules. The gut microbiome in participants with high-grade thyroid nodules is characterized by greater amino acid degradation and lower butyrate production. The relative abundances of multiple butyrate producing microbes are reduced in patients with high-grade thyroid nodules and the relative abundances of L-histidine metabolism pathways are associated with thyrotropin-releasing hormone. Our study describes the gut microbiome characteristics in thyroid nodules and a gut-thyroid link and highlight specific gut microbiota as a potential therapeutic target to regulate thyroid metabolism. Frontiers Media S.A. 2021-03-12 /pmc/articles/PMC8005713/ /pubmed/33791245 http://dx.doi.org/10.3389/fcimb.2021.643968 Text en Copyright © 2021 Li, Li, Gao, Yan, Chen, Huang, Wang, Yin, Li, Ma, Zeng and Ding http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Li, Ang
Li, Tiantian
Gao, Xinxin
Yan, Hang
Chen, Jingfeng
Huang, Meng
Wang, Lin
Yin, Detao
Li, Hongqiang
Ma, Runsheng
Zeng, Qiang
Ding, Suying
Gut Microbiome Alterations in Patients With Thyroid Nodules
title Gut Microbiome Alterations in Patients With Thyroid Nodules
title_full Gut Microbiome Alterations in Patients With Thyroid Nodules
title_fullStr Gut Microbiome Alterations in Patients With Thyroid Nodules
title_full_unstemmed Gut Microbiome Alterations in Patients With Thyroid Nodules
title_short Gut Microbiome Alterations in Patients With Thyroid Nodules
title_sort gut microbiome alterations in patients with thyroid nodules
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005713/
https://www.ncbi.nlm.nih.gov/pubmed/33791245
http://dx.doi.org/10.3389/fcimb.2021.643968
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