Manufacturing NKG2D CAR-T cells with piggyBac transposon vectors and K562 artificial antigen-presenting cells

Non-viral platforms can be applied rapidly and cost-effectively for chimeric antigen receptor (CAR)-T cell manufacturing. In the present paper, we describe in detail a clinically relevant manufacturing process for NKG2D CAR-T cells through electroporation of CAR-encoding piggyBac transposon plasmids...

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Detalles Bibliográficos
Autores principales: Tay, Johan C.K., Wang, Junjian, Du, Zhicheng, Ng, Yu Yang, Li, Zhendong, Ren, Yuefang, Zhang, Chang, Zhu, Jianqing, Xu, Xue Hu, Wang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005737/
https://www.ncbi.nlm.nih.gov/pubmed/33816644
http://dx.doi.org/10.1016/j.omtm.2021.02.023

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