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Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids
Endogenous oxidized phospholipids are produced during tissue stress and are responsible for sustaining inflammatory responses in immune as well as non-immune cells. Their local and systemic production and accumulation is associated with the etiology and progression of several inflammatory diseases,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005915/ https://www.ncbi.nlm.nih.gov/pubmed/33790857 http://dx.doi.org/10.3389/fendo.2021.626842 |
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author | Di Gioia, Marco Zanoni, Ivan |
author_facet | Di Gioia, Marco Zanoni, Ivan |
author_sort | Di Gioia, Marco |
collection | PubMed |
description | Endogenous oxidized phospholipids are produced during tissue stress and are responsible for sustaining inflammatory responses in immune as well as non-immune cells. Their local and systemic production and accumulation is associated with the etiology and progression of several inflammatory diseases, but the molecular mechanisms that underlie the biological activities of these oxidized phospholipids remain elusive. Increasing evidence highlights the ability of these stress mediators to modulate cellular metabolism and pro-inflammatory signaling in phagocytes, such as macrophages and dendritic cells, and to alter the activation and polarization of these cells. Because these immune cells serve a key role in maintaining tissue homeostasis and organ function, understanding how endogenous oxidized lipids reshape phagocyte biology and function is vital for designing clinical tools and interventions for preventing, slowing down, or resolving chronic inflammatory disorders that are driven by phagocyte dysfunction. Here, we discuss the metabolic and signaling processes elicited by endogenous oxidized lipids and outline new hypotheses and models to elucidate the impact of these lipids on phagocytes and inflammation. |
format | Online Article Text |
id | pubmed-8005915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80059152021-03-30 Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids Di Gioia, Marco Zanoni, Ivan Front Endocrinol (Lausanne) Endocrinology Endogenous oxidized phospholipids are produced during tissue stress and are responsible for sustaining inflammatory responses in immune as well as non-immune cells. Their local and systemic production and accumulation is associated with the etiology and progression of several inflammatory diseases, but the molecular mechanisms that underlie the biological activities of these oxidized phospholipids remain elusive. Increasing evidence highlights the ability of these stress mediators to modulate cellular metabolism and pro-inflammatory signaling in phagocytes, such as macrophages and dendritic cells, and to alter the activation and polarization of these cells. Because these immune cells serve a key role in maintaining tissue homeostasis and organ function, understanding how endogenous oxidized lipids reshape phagocyte biology and function is vital for designing clinical tools and interventions for preventing, slowing down, or resolving chronic inflammatory disorders that are driven by phagocyte dysfunction. Here, we discuss the metabolic and signaling processes elicited by endogenous oxidized lipids and outline new hypotheses and models to elucidate the impact of these lipids on phagocytes and inflammation. Frontiers Media S.A. 2021-03-15 /pmc/articles/PMC8005915/ /pubmed/33790857 http://dx.doi.org/10.3389/fendo.2021.626842 Text en Copyright © 2021 Di Gioia and Zanoni http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Di Gioia, Marco Zanoni, Ivan Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids |
title | Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids |
title_full | Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids |
title_fullStr | Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids |
title_full_unstemmed | Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids |
title_short | Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids |
title_sort | dooming phagocyte responses: inflammatory effects of endogenous oxidized phospholipids |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005915/ https://www.ncbi.nlm.nih.gov/pubmed/33790857 http://dx.doi.org/10.3389/fendo.2021.626842 |
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