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Divergent Importance of Chronobiological Considerations in High- and Low-dose Melatonin Therapies
Melatonin has been used preclinically and clinically for different purposes. Some applications are related to readjustment of circadian oscillators, others use doses that exceed the saturation of melatonin receptors MT(1) and MT(2) and are unsuitable for chronobiological purposes. Conditions are out...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006026/ https://www.ncbi.nlm.nih.gov/pubmed/33803450 http://dx.doi.org/10.3390/diseases9010018 |