The relationship of lipid peroxidation and antioxidant status to selected modifiable risk factors in coronary artery disease patients

BACKGROUND: Coronary artery disease (CAD) is found to be associated with a wide range of modifiable and non-modifiable risk factors. AIM OF THE STUDY: To evaluate the relationship of lipid peroxidation and antioxidant status to selected modifiable risk factors in angiographically proven CAD patients. METHODS: 150 angiographically proven CAD patients were categorized into three, based on selected risk factors. Data was collected using proforma and from hospital records. Peroxidation and antioxidant levels in blood samples were assessed using standard procedures. RESULTS: In category, I, significantly higher level of lipid peroxidation and the lower enzymatic antioxidant level were observed in patients with diabetes, hypertension, and with both diabetes and hypertension, when compared with patients without these clinical characteristics (p < 0.01). Similar results obtained for patients following a non-vegetarian diet when compared with patients following a vegetarian diet (category II). In BMI based group (category III), patients with BMI>25kg/m2 showed a significant increase in peroxidation and low enzymatic and non-enzymatic antioxidant levels than those with normal BMI. CONCLUSION: The study confirmed a strong association between selected modifiable risk factors, higher lipid peroxidation, and lower antioxidant levels in angiographically proven CAD patients. This provides leads in the management of cardiovascular events in CAD patients.