Cargando…

Why pancreatic islets should be regarded and regulated like organs

There are strong reasons to say that pancreatic islets are organs before they are isolated and that they should be considered to be organs once transplanted. Thus, taking into account how much we have learned about the structure and function of islet micro-organs, it seems highly illogical to on one...

Descripción completa

Detalles Bibliográficos
Autores principales: Weir, G. C., Bonner-Weir, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006072/
https://www.ncbi.nlm.nih.gov/pubmed/33786336
http://dx.doi.org/10.32113/cellr4_20213_3083
_version_ 1783672241042489344
author Weir, G. C.
Bonner-Weir, S.
author_facet Weir, G. C.
Bonner-Weir, S.
author_sort Weir, G. C.
collection PubMed
description There are strong reasons to say that pancreatic islets are organs before they are isolated and that they should be considered to be organs once transplanted. Thus, taking into account how much we have learned about the structure and function of islet micro-organs, it seems highly illogical to on one hand consider autologous islets be regulated as organ transplants and alloislets to be regulated with the very restrictive rules used for cell transplantation. It is particularly problematic that this policy has led to restrictions that have made it next to impossible for transplants of alloislets to be carried out in the US, which is a very sad situation for the country that made so many of the advances that brought islet transplantation to the clinic.
format Online
Article
Text
id pubmed-8006072
institution National Center for Biotechnology Information
language English
publishDate 2021
record_format MEDLINE/PubMed
spelling pubmed-80060722021-03-29 Why pancreatic islets should be regarded and regulated like organs Weir, G. C. Bonner-Weir, S. CellR4 Repair Replace Regen Reprogram Article There are strong reasons to say that pancreatic islets are organs before they are isolated and that they should be considered to be organs once transplanted. Thus, taking into account how much we have learned about the structure and function of islet micro-organs, it seems highly illogical to on one hand consider autologous islets be regulated as organ transplants and alloislets to be regulated with the very restrictive rules used for cell transplantation. It is particularly problematic that this policy has led to restrictions that have made it next to impossible for transplants of alloislets to be carried out in the US, which is a very sad situation for the country that made so many of the advances that brought islet transplantation to the clinic. 2021-03-16 2021 /pmc/articles/PMC8006072/ /pubmed/33786336 http://dx.doi.org/10.32113/cellr4_20213_3083 Text en This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Article
Weir, G. C.
Bonner-Weir, S.
Why pancreatic islets should be regarded and regulated like organs
title Why pancreatic islets should be regarded and regulated like organs
title_full Why pancreatic islets should be regarded and regulated like organs
title_fullStr Why pancreatic islets should be regarded and regulated like organs
title_full_unstemmed Why pancreatic islets should be regarded and regulated like organs
title_short Why pancreatic islets should be regarded and regulated like organs
title_sort why pancreatic islets should be regarded and regulated like organs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006072/
https://www.ncbi.nlm.nih.gov/pubmed/33786336
http://dx.doi.org/10.32113/cellr4_20213_3083
work_keys_str_mv AT weirgc whypancreaticisletsshouldberegardedandregulatedlikeorgans
AT bonnerweirs whypancreaticisletsshouldberegardedandregulatedlikeorgans