Cargando…

Precision therapeutic targets for COVID-19

Beginning in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a novel pathogen that causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 has infected more than 111 million people worldwide and caused over 2.47 million deaths. Individuals infected with SARS-CoV-2 s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krumm, Zachary A., Lloyd, Grace M., Francis, Connor P., Nasif, Lith H., Mitchell, Duane A., Golde, Todd E., Giasson, Benoit I., Xia, Yuxing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006140/ https://www.ncbi.nlm.nih.gov/pubmed/33781287 http://dx.doi.org/10.1186/s12985-021-01526-y

Ejemplares similares

Targeted proteolytic products of τ and α-synuclein in neurodegeneration
por: Xia, Yuxing, et al.
Publicado: (2021)

“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies
por: Xia, Yuxing, et al.
Publicado: (2021)

Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice
por: Xia, Yuxing, et al.
Publicado: (2022)

Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies
por: Hass, Ethan W., et al.
Publicado: (2021)

Designing antibodies against LRRK2-targeted tau epitopes
por: Hamm, Matthew, et al.
Publicado: (2018)

Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation
por: Xia, Yuxing, et al.
Publicado: (2021)

Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation
por: Xia, Yuxing, et al.
Publicado: (2023)

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau
por: Croft, Cara L., et al.
Publicado: (2018)

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity
por: Sorrentino, Zachary A., et al.
Publicado: (2017)

Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114
por: Quintin, Stephan, et al.
Publicado: (2023)

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice
por: Koller, Emily J., et al.
Publicado: (2017)

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau
por: Strang, Kevin H., et al.
Publicado: (2017)

Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation
por: Xia, Yuxing, et al.
Publicado: (2023)

Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
por: Lloyd, Grace M., et al.
Publicado: (2021)

Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease
por: Lloyd, Grace M., et al.
Publicado: (2020)

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies
por: Dhillon, Jess-Karan S., et al.
Publicado: (2017)

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy
por: Hass, Ethan W., et al.
Publicado: (2021)

Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes
por: Goodwin, Marshall S., et al.
Publicado: (2021)

Conformational templating of α-synuclein aggregates in neuronal-glial cultures
por: Sacino, Amanda N, et al.
Publicado: (2013)

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice
por: Rutherford, Nicola J., et al.
Publicado: (2015)

The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease
por: Golde, Todd E
Publicado: (2009)

Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies
por: Xia, Yuxing, et al.
Publicado: (2020)

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
por: Sacino, Amanda N, et al.
Publicado: (2013)

Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance
por: Croft, Cara L., et al.
Publicado: (2022)

Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression
por: Sorrentino, Zachary A., et al.
Publicado: (2019)

Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis
por: Lloyd, Grace M., et al.
Publicado: (2023)

Combining targeted therapeutics in the era of precision medicine
por: Papadatos-Pastos, D, et al.
Publicado: (2015)

Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy
por: Williams, Tosha, et al.
Publicado: (2020)

Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
por: Uchihara, Toshiki, et al.
Publicado: (2015)

Precise Therapeutic Targeting of Distinct NRXN1(+/−) Mutations
por: Fernando, Michael B., et al.
Publicado: (2023)

Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology?
por: Sacino, Amanda N, et al.
Publicado: (2012)

Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions
por: Croft, Cara L., et al.
Publicado: (2021)

A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies
por: Moore, Brenda D., et al.
Publicado: (2023)

Targeting cancer metabolism in the era of precision oncology
por: Stine, Zachary E., et al.
Publicado: (2021)

Precision therapeutic targeting of human cancer cell motility
por: Xu, Li, et al.
Publicado: (2018)

Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes
por: Rutherford, Nicola J., et al.
Publicado: (2016)

Immune targets for therapeutic development in depression: towards precision medicine
por: Drevets, Wayne C., et al.
Publicado: (2022)

IMMU-21. ELUCIDATING THE CELLULAR MECHANISMS OF THERAPEUTIC BENEFIT UNDERLYING ADOPTIVE CELLULAR THERAPY IN MODELS OF GLIOMA
por: Figg, John, et al.
Publicado: (2023)

Adult precision medicine: learning from the past to enhance the future
por: Ghiaseddin, Ashley, et al.
Publicado: (2020)

Therapeutic Targeting of ALK in Neuroblastoma: Experience of Italian Precision Medicine in Pediatric Oncology
por: Pastorino, Fabio, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hp23aa0k6accmv3nedp6tk26em