Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure–Activity Relationships and Optimization

[Image: see text] Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly challenging, as its receptors are heteromers comprising two distinct components: the calcitonin receptor-like receptor (CLR) or cal...

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Detalles Bibliográficos
Autores principales: Zirimwabagabo, Jean-Olivier, Jailani, Ameera B. A., Avgoustou, Paris, Tozer, Matthew J., Gibson, Karl R., Glossop, Paul A., Mills, James E. J., Porter, Roderick A., Blaney, Paul, Wang, Ning, Skerry, Timothy M., Richards, Gareth O., Harrity, Joseph P. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006142/
https://www.ncbi.nlm.nih.gov/pubmed/33666424
http://dx.doi.org/10.1021/acs.jmedchem.0c02191

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