Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumanniivia Dysregulation of Heme Biosynthesis

[Image: see text] Isonitrile natural products exhibit promising antibacterial activities. However, their mechanism of action (MoA) remains largely unknown. Based on the nanomolar potency of xanthocillin X (Xan) against diverse difficult-to-treat Gram-negative bacteria, including the critical priorit...

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Detalles Bibliográficos
Autores principales: Hübner, Ines, Shapiro, Justin A., Hoßmann, Jörn, Drechsel, Jonas, Hacker, Stephan M., Rather, Philip N., Pieper, Dietmar H., Wuest, William M., Sieber, Stephan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006170/
https://www.ncbi.nlm.nih.gov/pubmed/33791430
http://dx.doi.org/10.1021/acscentsci.0c01621

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