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Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space

For humans and other mammals to eat effectively, teeth must develop properly inside the jaw. Deciphering craniodental integration is central to explaining the timely formation of permanent molars, including third molars which are often impacted in humans, and to clarifying how teeth and jaws fit, fu...

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Autores principales: Ko, Daisy (Jihyung), Kelly, Tess, Thompson, Lacey, Uppal, Jasmene K., Rostampour, Nasim, Webb, Mark Adam, Zhu, Ning, Belev, George, Mondal, Prosanta, Cooper, David M. L., Boughner, Julia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006249/
https://www.ncbi.nlm.nih.gov/pubmed/33809066
http://dx.doi.org/10.3390/jdb9010008
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author Ko, Daisy (Jihyung)
Kelly, Tess
Thompson, Lacey
Uppal, Jasmene K.
Rostampour, Nasim
Webb, Mark Adam
Zhu, Ning
Belev, George
Mondal, Prosanta
Cooper, David M. L.
Boughner, Julia C.
author_facet Ko, Daisy (Jihyung)
Kelly, Tess
Thompson, Lacey
Uppal, Jasmene K.
Rostampour, Nasim
Webb, Mark Adam
Zhu, Ning
Belev, George
Mondal, Prosanta
Cooper, David M. L.
Boughner, Julia C.
author_sort Ko, Daisy (Jihyung)
collection PubMed
description For humans and other mammals to eat effectively, teeth must develop properly inside the jaw. Deciphering craniodental integration is central to explaining the timely formation of permanent molars, including third molars which are often impacted in humans, and to clarifying how teeth and jaws fit, function and evolve together. A factor long-posited to influence molar onset time is the jaw space available for each molar organ to form within. Here, we tested whether each successive molar initiates only after a minimum threshold of space is created via jaw growth. We used synchrotron-based micro-CT scanning to assess developing molars in situ within jaws of C57BL/6J mice aged E10 to P32, encompassing molar onset to emergence. We compared total jaw, retromolar and molar lengths, and molar onset times, between upper and lower jaws. Initiation time and developmental duration were comparable between molar upper and lower counterparts despite shorter, slower-growing retromolar space in the upper jaw, and despite size differences between upper and lower molars. Timing of molar formation appears unmoved by jaw length including space. Conditions within the dental lamina likely influence molar onset much more than surrounding jaw tissues. We theorize that molar initiation is contingent on sufficient surface area for the physical reorganization of dental epithelium and its invagination of underlying mesenchyme.
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spelling pubmed-80062492021-03-30 Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space Ko, Daisy (Jihyung) Kelly, Tess Thompson, Lacey Uppal, Jasmene K. Rostampour, Nasim Webb, Mark Adam Zhu, Ning Belev, George Mondal, Prosanta Cooper, David M. L. Boughner, Julia C. J Dev Biol Article For humans and other mammals to eat effectively, teeth must develop properly inside the jaw. Deciphering craniodental integration is central to explaining the timely formation of permanent molars, including third molars which are often impacted in humans, and to clarifying how teeth and jaws fit, function and evolve together. A factor long-posited to influence molar onset time is the jaw space available for each molar organ to form within. Here, we tested whether each successive molar initiates only after a minimum threshold of space is created via jaw growth. We used synchrotron-based micro-CT scanning to assess developing molars in situ within jaws of C57BL/6J mice aged E10 to P32, encompassing molar onset to emergence. We compared total jaw, retromolar and molar lengths, and molar onset times, between upper and lower jaws. Initiation time and developmental duration were comparable between molar upper and lower counterparts despite shorter, slower-growing retromolar space in the upper jaw, and despite size differences between upper and lower molars. Timing of molar formation appears unmoved by jaw length including space. Conditions within the dental lamina likely influence molar onset much more than surrounding jaw tissues. We theorize that molar initiation is contingent on sufficient surface area for the physical reorganization of dental epithelium and its invagination of underlying mesenchyme. MDPI 2021-03-12 /pmc/articles/PMC8006249/ /pubmed/33809066 http://dx.doi.org/10.3390/jdb9010008 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ko, Daisy (Jihyung)
Kelly, Tess
Thompson, Lacey
Uppal, Jasmene K.
Rostampour, Nasim
Webb, Mark Adam
Zhu, Ning
Belev, George
Mondal, Prosanta
Cooper, David M. L.
Boughner, Julia C.
Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space
title Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space
title_full Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space
title_fullStr Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space
title_full_unstemmed Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space
title_short Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space
title_sort timing of mouse molar formation is independent of jaw length including retromolar space
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006249/
https://www.ncbi.nlm.nih.gov/pubmed/33809066
http://dx.doi.org/10.3390/jdb9010008
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