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Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health

Well-established literature indicates that older adults have poorer cerebral white matter integrity, as measured through diffusion tensor imaging (DTI). Age differences in DTI have been observed widely across white matter, although some tracts appear more sensitive to the effects of aging than other...

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Autores principales: Matijevic, Stephanie, Ryan, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006297/
https://www.ncbi.nlm.nih.gov/pubmed/33790778
http://dx.doi.org/10.3389/fnagi.2021.628865
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author Matijevic, Stephanie
Ryan, Lee
author_facet Matijevic, Stephanie
Ryan, Lee
author_sort Matijevic, Stephanie
collection PubMed
description Well-established literature indicates that older adults have poorer cerebral white matter integrity, as measured through diffusion tensor imaging (DTI). Age differences in DTI have been observed widely across white matter, although some tracts appear more sensitive to the effects of aging than others. Factors like APOE ε4 status and sex may contribute to individual differences in white matter integrity that also selectively impact certain tracts, and could influence DTI changes in aging. The present study explored the degree to which age, APOE ε4, and sex exerted global vs. tract specific effects on DTI metrics in cognitively healthy late middle-aged to older adults. Data from 49 older adults (ages 54–92) at two time-points separated by approximately 2.7 years were collected. DTI metrics, including fractional anisotropy (FA) and mean diffusivity (MD), were extracted from nine white matter tracts and global white matter. Results showed that across timepoints, FA and MD increased globally, with no tract-specific changes observed. Baseline age had a global influence on both measures, with increasing age associated with lower FA and higher MD. After controlling for global white matter FA, age additionally predicted FA for the genu, callosum body, inferior fronto-occipital fasciculus (IFOF), and both anterior and posterior cingulum. Females exhibited lower global FA on average compared to males. In contrast, MD was selectively elevated in the anterior cingulum and superior longitudinal fasciculus (SLF), for females compared to males. APOE ε4 status was not predictive of either measure. In summary, these results indicate that age and sex are associated with both global and tract-specific alterations to DTI metrics among a healthy older adult cohort. Older women have poorer white matter integrity compared to older men, perhaps related to menopause-induced metabolic changes. While age-related alterations to white matter integrity are global, there is substantial variation in the degree to which tracts are impacted, possibly as a consequence of tract anatomical variability. The present study highlights the importance of accounting for global sources of variation in DTI metrics when attempting to investigate individual differences (due to age, sex, or other factors) in specific white matter tracts.
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spelling pubmed-80062972021-03-30 Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health Matijevic, Stephanie Ryan, Lee Front Aging Neurosci Neuroscience Well-established literature indicates that older adults have poorer cerebral white matter integrity, as measured through diffusion tensor imaging (DTI). Age differences in DTI have been observed widely across white matter, although some tracts appear more sensitive to the effects of aging than others. Factors like APOE ε4 status and sex may contribute to individual differences in white matter integrity that also selectively impact certain tracts, and could influence DTI changes in aging. The present study explored the degree to which age, APOE ε4, and sex exerted global vs. tract specific effects on DTI metrics in cognitively healthy late middle-aged to older adults. Data from 49 older adults (ages 54–92) at two time-points separated by approximately 2.7 years were collected. DTI metrics, including fractional anisotropy (FA) and mean diffusivity (MD), were extracted from nine white matter tracts and global white matter. Results showed that across timepoints, FA and MD increased globally, with no tract-specific changes observed. Baseline age had a global influence on both measures, with increasing age associated with lower FA and higher MD. After controlling for global white matter FA, age additionally predicted FA for the genu, callosum body, inferior fronto-occipital fasciculus (IFOF), and both anterior and posterior cingulum. Females exhibited lower global FA on average compared to males. In contrast, MD was selectively elevated in the anterior cingulum and superior longitudinal fasciculus (SLF), for females compared to males. APOE ε4 status was not predictive of either measure. In summary, these results indicate that age and sex are associated with both global and tract-specific alterations to DTI metrics among a healthy older adult cohort. Older women have poorer white matter integrity compared to older men, perhaps related to menopause-induced metabolic changes. While age-related alterations to white matter integrity are global, there is substantial variation in the degree to which tracts are impacted, possibly as a consequence of tract anatomical variability. The present study highlights the importance of accounting for global sources of variation in DTI metrics when attempting to investigate individual differences (due to age, sex, or other factors) in specific white matter tracts. Frontiers Media S.A. 2021-03-15 /pmc/articles/PMC8006297/ /pubmed/33790778 http://dx.doi.org/10.3389/fnagi.2021.628865 Text en Copyright © 2021 Matijevic and Ryan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Matijevic, Stephanie
Ryan, Lee
Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health
title Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health
title_full Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health
title_fullStr Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health
title_full_unstemmed Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health
title_short Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health
title_sort tract specificity of age effects on diffusion tensor imaging measures of white matter health
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006297/
https://www.ncbi.nlm.nih.gov/pubmed/33790778
http://dx.doi.org/10.3389/fnagi.2021.628865
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