Comprehensive identification of somatic nucleotide variants in human brain tissue

BACKGROUND: Post-zygotic mutations incurred during DNA replication, DNA repair, and other cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of various diseases, including cancers. However, detecting mosaic variants in DNA from non-cancerous somatic tissues poses...

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Detalles Bibliográficos
Autores principales: Wang, Yifan, Bae, Taejeong, Thorpe, Jeremy, Sherman, Maxwell A., Jones, Attila G., Cho, Sean, Daily, Kenneth, Dou, Yanmei, Ganz, Javier, Galor, Alon, Lobon, Irene, Pattni, Reenal, Rosenbluh, Chaggai, Tomasi, Simone, Tomasini, Livia, Yang, Xiaoxu, Zhou, Bo, Akbarian, Schahram, Ball, Laurel L., Bizzotto, Sara, Emery, Sarah B., Doan, Ryan, Fasching, Liana, Jang, Yeongjun, Juan, David, Lizano, Esther, Luquette, Lovelace J., Moldovan, John B., Narurkar, Rujuta, Oetjens, Matthew T., Rodin, Rachel E., Sekar, Shobana, Shin, Joo Heon, Soriano, Eduardo, Straub, Richard E., Zhou, Weichen, Chess, Andrew, Gleeson, Joseph G., Marquès-Bonet, Tomas, Park, Peter J., Peters, Mette A., Pevsner, Jonathan, Walsh, Christopher A., Weinberger, Daniel R., Vaccarino, Flora M., Moran, John V., Urban, Alexander E., Kidd, Jeffrey M., Mills, Ryan E., Abyzov, Alexej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006362/
https://www.ncbi.nlm.nih.gov/pubmed/33781308
http://dx.doi.org/10.1186/s13059-021-02285-3

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