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NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women
Associations of endothelial nitric oxide synthase (NOS3) polymorphisms with hypertension and response to exercise training in prehypertensive and hypertensive older adult women remain unclear. This study used a multicomponent program (various capacities and motor skills) in the physical training int...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006435/ https://www.ncbi.nlm.nih.gov/pubmed/33790801 http://dx.doi.org/10.3389/fphys.2021.566023 |
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author | Trapé, Átila Alexandre Rodrigues, Jhennyfer Aline Lima Ferezin, Letícia Perticarrara Ferrari, Gustavo Duarte Lizzi, Elisangela Aparecida da Silva de Moraes, Vitor Nolasco da Silva, Roberta Fernanda Zago, Anderson Saranz Brazo-Sayavera, Javier Bueno Júnior, Carlos Roberto |
author_facet | Trapé, Átila Alexandre Rodrigues, Jhennyfer Aline Lima Ferezin, Letícia Perticarrara Ferrari, Gustavo Duarte Lizzi, Elisangela Aparecida da Silva de Moraes, Vitor Nolasco da Silva, Roberta Fernanda Zago, Anderson Saranz Brazo-Sayavera, Javier Bueno Júnior, Carlos Roberto |
author_sort | Trapé, Átila Alexandre |
collection | PubMed |
description | Associations of endothelial nitric oxide synthase (NOS3) polymorphisms with hypertension and response to exercise training in prehypertensive and hypertensive older adult women remain unclear. This study used a multicomponent program (various capacities and motor skills) in the physical training intervention. It analyzed the influence of NOS3 polymorphisms [−786T > C, 894G > T (Glu298Asp), and intron 4b/a] on the response of blood pressure (BP), nitrite concentration, and physical fitness in older adult women. Fifty-two participants aged between 50 and 80 underwent body mass index, BP, 6-min walk, elbow flexion, and sit and stand-up tests to assess physical fitness. The intervention duration was 12 weeks, twice a week, on non-consecutive days. Each session lasted 90 min, maintaining an intensity between 13 (moderate) and 15 (intense), controlled by the Subjective Effort Perception Scale. Plasma/blood samples were collected to assess nitrite concentration and genotyping. The statistical analysis included Fisher’s exact test and linear mixed-effects models. The multicomponent training’s positive effect was observed with a similar response in both prehypertensive and hypertensive groups. However, carriers of different genotypes demonstrated different responses to training: the decreases in systolic and diastolic BP and increases in nitrite expected from the physical training were smaller in variant genotype than ancestral genotype carriers, especially in the hypertensive group. At positions −786T > C and Glu298Asp, only the ancestral genotypes showed a decrease in diastolic BP (Δ% = −8.1, and Δ% = −6.5, respectively) and an increase on nitrite (Δ% = 19.1, and Δ% = 24.1, respectively) in the hypertensive group. Our results show that the benefits of a multicomponent training intervention seem to be genotype-dependent. It should be possible to consider genetic variants when selecting an exercise treatment intervention. |
format | Online Article Text |
id | pubmed-8006435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80064352021-03-30 NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women Trapé, Átila Alexandre Rodrigues, Jhennyfer Aline Lima Ferezin, Letícia Perticarrara Ferrari, Gustavo Duarte Lizzi, Elisangela Aparecida da Silva de Moraes, Vitor Nolasco da Silva, Roberta Fernanda Zago, Anderson Saranz Brazo-Sayavera, Javier Bueno Júnior, Carlos Roberto Front Physiol Physiology Associations of endothelial nitric oxide synthase (NOS3) polymorphisms with hypertension and response to exercise training in prehypertensive and hypertensive older adult women remain unclear. This study used a multicomponent program (various capacities and motor skills) in the physical training intervention. It analyzed the influence of NOS3 polymorphisms [−786T > C, 894G > T (Glu298Asp), and intron 4b/a] on the response of blood pressure (BP), nitrite concentration, and physical fitness in older adult women. Fifty-two participants aged between 50 and 80 underwent body mass index, BP, 6-min walk, elbow flexion, and sit and stand-up tests to assess physical fitness. The intervention duration was 12 weeks, twice a week, on non-consecutive days. Each session lasted 90 min, maintaining an intensity between 13 (moderate) and 15 (intense), controlled by the Subjective Effort Perception Scale. Plasma/blood samples were collected to assess nitrite concentration and genotyping. The statistical analysis included Fisher’s exact test and linear mixed-effects models. The multicomponent training’s positive effect was observed with a similar response in both prehypertensive and hypertensive groups. However, carriers of different genotypes demonstrated different responses to training: the decreases in systolic and diastolic BP and increases in nitrite expected from the physical training were smaller in variant genotype than ancestral genotype carriers, especially in the hypertensive group. At positions −786T > C and Glu298Asp, only the ancestral genotypes showed a decrease in diastolic BP (Δ% = −8.1, and Δ% = −6.5, respectively) and an increase on nitrite (Δ% = 19.1, and Δ% = 24.1, respectively) in the hypertensive group. Our results show that the benefits of a multicomponent training intervention seem to be genotype-dependent. It should be possible to consider genetic variants when selecting an exercise treatment intervention. Frontiers Media S.A. 2021-03-10 /pmc/articles/PMC8006435/ /pubmed/33790801 http://dx.doi.org/10.3389/fphys.2021.566023 Text en Copyright © 2021 Trapé, Rodrigues, Ferezin, Ferrari, Lizzi, Moraes, Silva, Zago, Brazo-Sayavera and Bueno Júnior. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Trapé, Átila Alexandre Rodrigues, Jhennyfer Aline Lima Ferezin, Letícia Perticarrara Ferrari, Gustavo Duarte Lizzi, Elisangela Aparecida da Silva de Moraes, Vitor Nolasco da Silva, Roberta Fernanda Zago, Anderson Saranz Brazo-Sayavera, Javier Bueno Júnior, Carlos Roberto NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women |
title | NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women |
title_full | NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women |
title_fullStr | NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women |
title_full_unstemmed | NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women |
title_short | NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women |
title_sort | nos3 polymorphisms can influence the effect of multicomponent training on blood pressure, nitrite concentration and physical fitness in prehypertensive and hypertensive older adult women |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006435/ https://www.ncbi.nlm.nih.gov/pubmed/33790801 http://dx.doi.org/10.3389/fphys.2021.566023 |
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