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Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M(pro) inhibitors

The main viral protease (M(pro)) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry M(pro) assay. The results reveal some β-lactams, including penicillin esters, are ac...

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Detalles Bibliográficos
Autores principales:	Malla, Tika R., Tumber, Anthony, John, Tobias, Brewitz, Lennart, Strain-Damerell, Claire, Owen, C David, Lukacik, Petra, Chan, H. T. Henry, Maheswaran, Pratheesh, Salah, Eidarus, Duarte, Fernanda, Yang, Haitao, Rao, Zihe, Walsh, Martin A., Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006714/ https://www.ncbi.nlm.nih.gov/pubmed/33462575 http://dx.doi.org/10.1039/d0cc06870e

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