Cargando…
Usefulness of CHADS2, R2CHADS2, and CHA2DS2‐VASc scores for predicting incident atrial fibrillation in heart failure with preserved ejection fraction patients
AIMS: Coexisting of atrial fibrillation (AF) in patients with heart failure with preserved ejection fraction (HFpEF) could increase the risk of mortality. In this study, we aimed to assess the values of the CHADS2, R2CHADS2, and CHA2DS2‐VASc scores for AF prediction in HFpEF patients. METHODS AND RE...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006733/ https://www.ncbi.nlm.nih.gov/pubmed/33506643 http://dx.doi.org/10.1002/ehf2.13217 |
_version_ | 1783672366964932608 |
---|---|
author | Wu, Yuzhong Xie, Zengshuo Liang, Weihao Xue, Ruicong Wu, Zexuan Wu, Dexi He, Jiangui Zhu, Wengen Liu, Chen |
author_facet | Wu, Yuzhong Xie, Zengshuo Liang, Weihao Xue, Ruicong Wu, Zexuan Wu, Dexi He, Jiangui Zhu, Wengen Liu, Chen |
author_sort | Wu, Yuzhong |
collection | PubMed |
description | AIMS: Coexisting of atrial fibrillation (AF) in patients with heart failure with preserved ejection fraction (HFpEF) could increase the risk of mortality. In this study, we aimed to assess the values of the CHADS2, R2CHADS2, and CHA2DS2‐VASc scores for AF prediction in HFpEF patients. METHODS AND RESULTS: We performed a retrospective analysis on symptomatic HFpEF patients in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial. Associations of the CHADS2, R2CHADS2, and CHA2DS2‐VASc scores with the risk of incident AF in HFpEF patients without baseline AF (n = 2202) were assessed using the multivariable competing risk regression models. The discriminatory performances of these scores were calculated using the C‐index. During a median follow‐up of 3.3 years, the average incidence of AF was 1.80 per 100 patient‐years in HFpEF patients. When score was analysed as a continuous variable, per 1‐point increase in the CHADS2 (hazard ratio [HR] = 1.42, 95% confidence interval [CI]: 1.20–1.68, C‐index: 0.71), R2CHADS2 (HR = 1.25, 95% CI: 1.10–1.42, C‐index: 0.69), or CHA2DS2‐VASc (HR = 1.30, 95% CI: 1.16–1.46, C‐index: 0.70) scores was associated with an increased risk of incident AF. When score was analysed as a categorical variable, patients with CHADS2 ≥ 3 (HR = 2.62, 95% CI: 1.70–4.04), R2CHADS2 ≥ 3 (HR = 2.55, 95% CI: 1.56–4.17), or CHA2DS2‐VASc ≥ 4 (HR = 2.54, 95% CI: 1.59–4.07) had a higher risk of incident AF compared with the corresponding controls. CONCLUSIONS: Our data first suggest that the CHADS2, R2CHADS2, and CHA2DS2‐VASc scores could predict the risk of incident AF in HFpEF patients with modest predictive abilities. |
format | Online Article Text |
id | pubmed-8006733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80067332021-04-01 Usefulness of CHADS2, R2CHADS2, and CHA2DS2‐VASc scores for predicting incident atrial fibrillation in heart failure with preserved ejection fraction patients Wu, Yuzhong Xie, Zengshuo Liang, Weihao Xue, Ruicong Wu, Zexuan Wu, Dexi He, Jiangui Zhu, Wengen Liu, Chen ESC Heart Fail Original Research Articles AIMS: Coexisting of atrial fibrillation (AF) in patients with heart failure with preserved ejection fraction (HFpEF) could increase the risk of mortality. In this study, we aimed to assess the values of the CHADS2, R2CHADS2, and CHA2DS2‐VASc scores for AF prediction in HFpEF patients. METHODS AND RESULTS: We performed a retrospective analysis on symptomatic HFpEF patients in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial. Associations of the CHADS2, R2CHADS2, and CHA2DS2‐VASc scores with the risk of incident AF in HFpEF patients without baseline AF (n = 2202) were assessed using the multivariable competing risk regression models. The discriminatory performances of these scores were calculated using the C‐index. During a median follow‐up of 3.3 years, the average incidence of AF was 1.80 per 100 patient‐years in HFpEF patients. When score was analysed as a continuous variable, per 1‐point increase in the CHADS2 (hazard ratio [HR] = 1.42, 95% confidence interval [CI]: 1.20–1.68, C‐index: 0.71), R2CHADS2 (HR = 1.25, 95% CI: 1.10–1.42, C‐index: 0.69), or CHA2DS2‐VASc (HR = 1.30, 95% CI: 1.16–1.46, C‐index: 0.70) scores was associated with an increased risk of incident AF. When score was analysed as a categorical variable, patients with CHADS2 ≥ 3 (HR = 2.62, 95% CI: 1.70–4.04), R2CHADS2 ≥ 3 (HR = 2.55, 95% CI: 1.56–4.17), or CHA2DS2‐VASc ≥ 4 (HR = 2.54, 95% CI: 1.59–4.07) had a higher risk of incident AF compared with the corresponding controls. CONCLUSIONS: Our data first suggest that the CHADS2, R2CHADS2, and CHA2DS2‐VASc scores could predict the risk of incident AF in HFpEF patients with modest predictive abilities. John Wiley and Sons Inc. 2021-01-27 /pmc/articles/PMC8006733/ /pubmed/33506643 http://dx.doi.org/10.1002/ehf2.13217 Text en © 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Articles Wu, Yuzhong Xie, Zengshuo Liang, Weihao Xue, Ruicong Wu, Zexuan Wu, Dexi He, Jiangui Zhu, Wengen Liu, Chen Usefulness of CHADS2, R2CHADS2, and CHA2DS2‐VASc scores for predicting incident atrial fibrillation in heart failure with preserved ejection fraction patients |
title | Usefulness of CHADS2, R2CHADS2, and CHA2DS2‐VASc scores for predicting incident atrial fibrillation in heart failure with preserved ejection fraction patients |
title_full | Usefulness of CHADS2, R2CHADS2, and CHA2DS2‐VASc scores for predicting incident atrial fibrillation in heart failure with preserved ejection fraction patients |
title_fullStr | Usefulness of CHADS2, R2CHADS2, and CHA2DS2‐VASc scores for predicting incident atrial fibrillation in heart failure with preserved ejection fraction patients |
title_full_unstemmed | Usefulness of CHADS2, R2CHADS2, and CHA2DS2‐VASc scores for predicting incident atrial fibrillation in heart failure with preserved ejection fraction patients |
title_short | Usefulness of CHADS2, R2CHADS2, and CHA2DS2‐VASc scores for predicting incident atrial fibrillation in heart failure with preserved ejection fraction patients |
title_sort | usefulness of chads2, r2chads2, and cha2ds2‐vasc scores for predicting incident atrial fibrillation in heart failure with preserved ejection fraction patients |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006733/ https://www.ncbi.nlm.nih.gov/pubmed/33506643 http://dx.doi.org/10.1002/ehf2.13217 |
work_keys_str_mv | AT wuyuzhong usefulnessofchads2r2chads2andcha2ds2vascscoresforpredictingincidentatrialfibrillationinheartfailurewithpreservedejectionfractionpatients AT xiezengshuo usefulnessofchads2r2chads2andcha2ds2vascscoresforpredictingincidentatrialfibrillationinheartfailurewithpreservedejectionfractionpatients AT liangweihao usefulnessofchads2r2chads2andcha2ds2vascscoresforpredictingincidentatrialfibrillationinheartfailurewithpreservedejectionfractionpatients AT xueruicong usefulnessofchads2r2chads2andcha2ds2vascscoresforpredictingincidentatrialfibrillationinheartfailurewithpreservedejectionfractionpatients AT wuzexuan usefulnessofchads2r2chads2andcha2ds2vascscoresforpredictingincidentatrialfibrillationinheartfailurewithpreservedejectionfractionpatients AT wudexi usefulnessofchads2r2chads2andcha2ds2vascscoresforpredictingincidentatrialfibrillationinheartfailurewithpreservedejectionfractionpatients AT hejiangui usefulnessofchads2r2chads2andcha2ds2vascscoresforpredictingincidentatrialfibrillationinheartfailurewithpreservedejectionfractionpatients AT zhuwengen usefulnessofchads2r2chads2andcha2ds2vascscoresforpredictingincidentatrialfibrillationinheartfailurewithpreservedejectionfractionpatients AT liuchen usefulnessofchads2r2chads2andcha2ds2vascscoresforpredictingincidentatrialfibrillationinheartfailurewithpreservedejectionfractionpatients |