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SARS-CoV-2 viral dynamics in non-human primates

Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large b...

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Detalles Bibliográficos
Autores principales: Gonçalves, Antonio, Maisonnasse, Pauline, Donati, Flora, Albert, Mélanie, Behillil, Sylvie, Contreras, Vanessa, Naninck, Thibaut, Marlin, Romain, Solas, Caroline, Pizzorno, Andres, Lemaitre, Julien, Kahlaoui, Nidhal, Terrier, Olivier, Ho Tsong Fang, Raphael, Enouf, Vincent, Dereuddre-Bosquet, Nathalie, Brisebarre, Angela, Touret, Franck, Chapon, Catherine, Hoen, Bruno, Lina, Bruno, Rosa Calatrava, Manuel, de Lamballerie, Xavier, Mentré, France, Le Grand, Roger, van der Werf, Sylvie, Guedj, Jérémie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007039/
https://www.ncbi.nlm.nih.gov/pubmed/33730053
http://dx.doi.org/10.1371/journal.pcbi.1008785
Descripción
Sumario:Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (>10(4) virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.