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SARS-CoV-2 viral dynamics in non-human primates
Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large b...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007039/ https://www.ncbi.nlm.nih.gov/pubmed/33730053 http://dx.doi.org/10.1371/journal.pcbi.1008785 |
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author | Gonçalves, Antonio Maisonnasse, Pauline Donati, Flora Albert, Mélanie Behillil, Sylvie Contreras, Vanessa Naninck, Thibaut Marlin, Romain Solas, Caroline Pizzorno, Andres Lemaitre, Julien Kahlaoui, Nidhal Terrier, Olivier Ho Tsong Fang, Raphael Enouf, Vincent Dereuddre-Bosquet, Nathalie Brisebarre, Angela Touret, Franck Chapon, Catherine Hoen, Bruno Lina, Bruno Rosa Calatrava, Manuel de Lamballerie, Xavier Mentré, France Le Grand, Roger van der Werf, Sylvie Guedj, Jérémie |
author_facet | Gonçalves, Antonio Maisonnasse, Pauline Donati, Flora Albert, Mélanie Behillil, Sylvie Contreras, Vanessa Naninck, Thibaut Marlin, Romain Solas, Caroline Pizzorno, Andres Lemaitre, Julien Kahlaoui, Nidhal Terrier, Olivier Ho Tsong Fang, Raphael Enouf, Vincent Dereuddre-Bosquet, Nathalie Brisebarre, Angela Touret, Franck Chapon, Catherine Hoen, Bruno Lina, Bruno Rosa Calatrava, Manuel de Lamballerie, Xavier Mentré, France Le Grand, Roger van der Werf, Sylvie Guedj, Jérémie |
author_sort | Gonçalves, Antonio |
collection | PubMed |
description | Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (>10(4) virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments. |
format | Online Article Text |
id | pubmed-8007039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80070392021-04-07 SARS-CoV-2 viral dynamics in non-human primates Gonçalves, Antonio Maisonnasse, Pauline Donati, Flora Albert, Mélanie Behillil, Sylvie Contreras, Vanessa Naninck, Thibaut Marlin, Romain Solas, Caroline Pizzorno, Andres Lemaitre, Julien Kahlaoui, Nidhal Terrier, Olivier Ho Tsong Fang, Raphael Enouf, Vincent Dereuddre-Bosquet, Nathalie Brisebarre, Angela Touret, Franck Chapon, Catherine Hoen, Bruno Lina, Bruno Rosa Calatrava, Manuel de Lamballerie, Xavier Mentré, France Le Grand, Roger van der Werf, Sylvie Guedj, Jérémie PLoS Comput Biol Research Article Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (>10(4) virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments. Public Library of Science 2021-03-17 /pmc/articles/PMC8007039/ /pubmed/33730053 http://dx.doi.org/10.1371/journal.pcbi.1008785 Text en © 2021 Gonçalves et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Gonçalves, Antonio Maisonnasse, Pauline Donati, Flora Albert, Mélanie Behillil, Sylvie Contreras, Vanessa Naninck, Thibaut Marlin, Romain Solas, Caroline Pizzorno, Andres Lemaitre, Julien Kahlaoui, Nidhal Terrier, Olivier Ho Tsong Fang, Raphael Enouf, Vincent Dereuddre-Bosquet, Nathalie Brisebarre, Angela Touret, Franck Chapon, Catherine Hoen, Bruno Lina, Bruno Rosa Calatrava, Manuel de Lamballerie, Xavier Mentré, France Le Grand, Roger van der Werf, Sylvie Guedj, Jérémie SARS-CoV-2 viral dynamics in non-human primates |
title | SARS-CoV-2 viral dynamics in non-human primates |
title_full | SARS-CoV-2 viral dynamics in non-human primates |
title_fullStr | SARS-CoV-2 viral dynamics in non-human primates |
title_full_unstemmed | SARS-CoV-2 viral dynamics in non-human primates |
title_short | SARS-CoV-2 viral dynamics in non-human primates |
title_sort | sars-cov-2 viral dynamics in non-human primates |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007039/ https://www.ncbi.nlm.nih.gov/pubmed/33730053 http://dx.doi.org/10.1371/journal.pcbi.1008785 |
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