Fast Heck–Cassar–Sonogashira (HCS) Reactions in Green Solvents

[Image: see text] The replacement of toxic solvents with greener alternatives in Heck–Cassar–Sonogashira (HCS) cross-couplings was investigated. The fine-tuning of the HCS protocol allowed to achieve complete conversions and high speed under mild conditions. N-Hydroxyethylpyrrolidone (HEP) gave the...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferrazzano, L., Martelli, G., Fantoni, T., Daka, A., Corbisiero, D., Viola, A., Ricci, A., Cabri, W., Tolomelli, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007125/
https://www.ncbi.nlm.nih.gov/pubmed/32342693
http://dx.doi.org/10.1021/acs.orglett.0c01269
Descripción
Sumario:[Image: see text] The replacement of toxic solvents with greener alternatives in Heck–Cassar–Sonogashira (HCS) cross-couplings was investigated. The fine-tuning of the HCS protocol allowed to achieve complete conversions and high speed under mild conditions. N-Hydroxyethylpyrrolidone (HEP) gave the best results. Moreover, the methodology was successfully applied to the synthesis of an intermediate of the anticancer drug Erlotinib, demonstrating the versatility of the new green protocol.

Ejemplares similares