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The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli
In mice, early exposure to environmental odors affects social behaviors later in life. A signaling molecule, Semaphorin 7A (Sema7A), is induced in the odor-responding olfactory sensory neurons. Plexin C1 (PlxnC1), a receptor for Sema7A, is expressed in mitral/tufted cells, whose dendrite-localizatio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007213/ https://www.ncbi.nlm.nih.gov/pubmed/33780330 http://dx.doi.org/10.7554/eLife.65078 |
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author | Inoue, Nobuko Nishizumi, Hirofumi Ooyama, Rumi Mogi, Kazutaka Nishimori, Katsuhiko Kikusui, Takefumi Sakano, Hitoshi |
author_facet | Inoue, Nobuko Nishizumi, Hirofumi Ooyama, Rumi Mogi, Kazutaka Nishimori, Katsuhiko Kikusui, Takefumi Sakano, Hitoshi |
author_sort | Inoue, Nobuko |
collection | PubMed |
description | In mice, early exposure to environmental odors affects social behaviors later in life. A signaling molecule, Semaphorin 7A (Sema7A), is induced in the odor-responding olfactory sensory neurons. Plexin C1 (PlxnC1), a receptor for Sema7A, is expressed in mitral/tufted cells, whose dendrite-localization is restricted to the first week after birth. Sema7A/PlxnC1 signaling promotes post-synaptic events and dendrite selection in mitral/tufted cells, resulting in glomerular enlargement that causes an increase in sensitivity to the experienced odor. Neonatal odor experience also induces positive responses to the imprinted odor. Knockout and rescue experiments indicate that oxytocin in neonates is responsible for imposing positive quality on imprinted memory. In the oxytocin knockout mice, the sensitivity to the imprinted odor increases, but positive responses cannot be promoted, indicating that Sema7A/PlxnC1 signaling and oxytocin separately function. These results give new insights into our understanding of olfactory imprinting during the neonatal critical period. |
format | Online Article Text |
id | pubmed-8007213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-80072132021-03-31 The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli Inoue, Nobuko Nishizumi, Hirofumi Ooyama, Rumi Mogi, Kazutaka Nishimori, Katsuhiko Kikusui, Takefumi Sakano, Hitoshi eLife Developmental Biology In mice, early exposure to environmental odors affects social behaviors later in life. A signaling molecule, Semaphorin 7A (Sema7A), is induced in the odor-responding olfactory sensory neurons. Plexin C1 (PlxnC1), a receptor for Sema7A, is expressed in mitral/tufted cells, whose dendrite-localization is restricted to the first week after birth. Sema7A/PlxnC1 signaling promotes post-synaptic events and dendrite selection in mitral/tufted cells, resulting in glomerular enlargement that causes an increase in sensitivity to the experienced odor. Neonatal odor experience also induces positive responses to the imprinted odor. Knockout and rescue experiments indicate that oxytocin in neonates is responsible for imposing positive quality on imprinted memory. In the oxytocin knockout mice, the sensitivity to the imprinted odor increases, but positive responses cannot be promoted, indicating that Sema7A/PlxnC1 signaling and oxytocin separately function. These results give new insights into our understanding of olfactory imprinting during the neonatal critical period. eLife Sciences Publications, Ltd 2021-03-29 /pmc/articles/PMC8007213/ /pubmed/33780330 http://dx.doi.org/10.7554/eLife.65078 Text en © 2021, Inoue et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Inoue, Nobuko Nishizumi, Hirofumi Ooyama, Rumi Mogi, Kazutaka Nishimori, Katsuhiko Kikusui, Takefumi Sakano, Hitoshi The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli |
title | The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli |
title_full | The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli |
title_fullStr | The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli |
title_full_unstemmed | The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli |
title_short | The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli |
title_sort | olfactory critical period is determined by activity-dependent sema7a/plxnc1 signaling within glomeruli |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007213/ https://www.ncbi.nlm.nih.gov/pubmed/33780330 http://dx.doi.org/10.7554/eLife.65078 |
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