Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

G4C2 repeat expansions within the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The repeats undergo repeat-associated non-ATG translation to generate toxic dipeptide repeat proteins. Here, we show that insulin/IGF signalling...

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Detalles Bibliográficos
Autores principales: Atilano, Magda L, Grönke, Sebastian, Niccoli, Teresa, Kempthorne, Liam, Hahn, Oliver, Morón-Oset, Javier, Hendrich, Oliver, Dyson, Miranda, Adams, Mirjam Lisette, Hull, Alexander, Salcher-Konrad, Marie-Therese, Monaghan, Amy, Bictash, Magda, Glaria, Idoia, Isaacs, Adrian M, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007214/
https://www.ncbi.nlm.nih.gov/pubmed/33739284
http://dx.doi.org/10.7554/eLife.58565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007214/
https://www.ncbi.nlm.nih.gov/pubmed/33739284
http://dx.doi.org/10.7554/eLife.58565

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