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Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients
Mucormycosis is an invasive, rapidly progressive, life-threatening fungal infection, with a propensity for diabetic, immunosuppressed, and trauma patients. The classic rhinocerebral variation is most common in diabetic patients. While the cutaneous form is usually caused by direct inoculation in imm...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Plastic and Reconstructive Surgeons
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007453/ https://www.ncbi.nlm.nih.gov/pubmed/33657778 http://dx.doi.org/10.5999/aps.2020.00549 |
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author | Coerdt, Kathleen M. Zolper, Elizabeth G. Starr, Amy G. Fan, Kenneth L. Attinger, Christopher E. Evans, Karen K. |
author_facet | Coerdt, Kathleen M. Zolper, Elizabeth G. Starr, Amy G. Fan, Kenneth L. Attinger, Christopher E. Evans, Karen K. |
author_sort | Coerdt, Kathleen M. |
collection | PubMed |
description | Mucormycosis is an invasive, rapidly progressive, life-threatening fungal infection, with a propensity for diabetic, immunosuppressed, and trauma patients. The classic rhinocerebral variation is most common in diabetic patients. While the cutaneous form is usually caused by direct inoculation in immunocompetent patients. Cutaneous mucormycosis manifests in soft tissue and risks involvement of underlying structures. Tibial osteomyelitis can also occur secondary to cutaneous mucormycosis but is rare. Limb salvage is typically successful after lower extremity cutaneous mucormycosis even when the bone is involved. Herein, we report two cases of lower extremity cutaneous mucormycosis in diabetic patients that presented as acute worsening of chronic pretibial ulcers. Despite aggressive antifungal therapy and surgical debridement, both ultimately required amputation. Such aggressive presentation has not been reported in the absence of major penetrating trauma, recent surgery, or burns. |
format | Online Article Text |
id | pubmed-8007453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society of Plastic and Reconstructive Surgeons |
record_format | MEDLINE/PubMed |
spelling | pubmed-80074532021-04-07 Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients Coerdt, Kathleen M. Zolper, Elizabeth G. Starr, Amy G. Fan, Kenneth L. Attinger, Christopher E. Evans, Karen K. Arch Plast Surg Extremity/Lymphedema Mucormycosis is an invasive, rapidly progressive, life-threatening fungal infection, with a propensity for diabetic, immunosuppressed, and trauma patients. The classic rhinocerebral variation is most common in diabetic patients. While the cutaneous form is usually caused by direct inoculation in immunocompetent patients. Cutaneous mucormycosis manifests in soft tissue and risks involvement of underlying structures. Tibial osteomyelitis can also occur secondary to cutaneous mucormycosis but is rare. Limb salvage is typically successful after lower extremity cutaneous mucormycosis even when the bone is involved. Herein, we report two cases of lower extremity cutaneous mucormycosis in diabetic patients that presented as acute worsening of chronic pretibial ulcers. Despite aggressive antifungal therapy and surgical debridement, both ultimately required amputation. Such aggressive presentation has not been reported in the absence of major penetrating trauma, recent surgery, or burns. Korean Society of Plastic and Reconstructive Surgeons 2021-03 2021-03-04 /pmc/articles/PMC8007453/ /pubmed/33657778 http://dx.doi.org/10.5999/aps.2020.00549 Text en Copyright © 2021 The Korean Society of Plastic and Reconstructive Surgeons This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Extremity/Lymphedema Coerdt, Kathleen M. Zolper, Elizabeth G. Starr, Amy G. Fan, Kenneth L. Attinger, Christopher E. Evans, Karen K. Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients |
title | Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients |
title_full | Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients |
title_fullStr | Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients |
title_full_unstemmed | Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients |
title_short | Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients |
title_sort | cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients |
topic | Extremity/Lymphedema |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007453/ https://www.ncbi.nlm.nih.gov/pubmed/33657778 http://dx.doi.org/10.5999/aps.2020.00549 |
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