Cargando…

Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients

Mucormycosis is an invasive, rapidly progressive, life-threatening fungal infection, with a propensity for diabetic, immunosuppressed, and trauma patients. The classic rhinocerebral variation is most common in diabetic patients. While the cutaneous form is usually caused by direct inoculation in imm...

Descripción completa

Detalles Bibliográficos
Autores principales: Coerdt, Kathleen M., Zolper, Elizabeth G., Starr, Amy G., Fan, Kenneth L., Attinger, Christopher E., Evans, Karen K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Plastic and Reconstructive Surgeons 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007453/
https://www.ncbi.nlm.nih.gov/pubmed/33657778
http://dx.doi.org/10.5999/aps.2020.00549
_version_ 1783672492269764608
author Coerdt, Kathleen M.
Zolper, Elizabeth G.
Starr, Amy G.
Fan, Kenneth L.
Attinger, Christopher E.
Evans, Karen K.
author_facet Coerdt, Kathleen M.
Zolper, Elizabeth G.
Starr, Amy G.
Fan, Kenneth L.
Attinger, Christopher E.
Evans, Karen K.
author_sort Coerdt, Kathleen M.
collection PubMed
description Mucormycosis is an invasive, rapidly progressive, life-threatening fungal infection, with a propensity for diabetic, immunosuppressed, and trauma patients. The classic rhinocerebral variation is most common in diabetic patients. While the cutaneous form is usually caused by direct inoculation in immunocompetent patients. Cutaneous mucormycosis manifests in soft tissue and risks involvement of underlying structures. Tibial osteomyelitis can also occur secondary to cutaneous mucormycosis but is rare. Limb salvage is typically successful after lower extremity cutaneous mucormycosis even when the bone is involved. Herein, we report two cases of lower extremity cutaneous mucormycosis in diabetic patients that presented as acute worsening of chronic pretibial ulcers. Despite aggressive antifungal therapy and surgical debridement, both ultimately required amputation. Such aggressive presentation has not been reported in the absence of major penetrating trauma, recent surgery, or burns.
format Online
Article
Text
id pubmed-8007453
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Korean Society of Plastic and Reconstructive Surgeons
record_format MEDLINE/PubMed
spelling pubmed-80074532021-04-07 Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients Coerdt, Kathleen M. Zolper, Elizabeth G. Starr, Amy G. Fan, Kenneth L. Attinger, Christopher E. Evans, Karen K. Arch Plast Surg Extremity/Lymphedema Mucormycosis is an invasive, rapidly progressive, life-threatening fungal infection, with a propensity for diabetic, immunosuppressed, and trauma patients. The classic rhinocerebral variation is most common in diabetic patients. While the cutaneous form is usually caused by direct inoculation in immunocompetent patients. Cutaneous mucormycosis manifests in soft tissue and risks involvement of underlying structures. Tibial osteomyelitis can also occur secondary to cutaneous mucormycosis but is rare. Limb salvage is typically successful after lower extremity cutaneous mucormycosis even when the bone is involved. Herein, we report two cases of lower extremity cutaneous mucormycosis in diabetic patients that presented as acute worsening of chronic pretibial ulcers. Despite aggressive antifungal therapy and surgical debridement, both ultimately required amputation. Such aggressive presentation has not been reported in the absence of major penetrating trauma, recent surgery, or burns. Korean Society of Plastic and Reconstructive Surgeons 2021-03 2021-03-04 /pmc/articles/PMC8007453/ /pubmed/33657778 http://dx.doi.org/10.5999/aps.2020.00549 Text en Copyright © 2021 The Korean Society of Plastic and Reconstructive Surgeons This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Extremity/Lymphedema
Coerdt, Kathleen M.
Zolper, Elizabeth G.
Starr, Amy G.
Fan, Kenneth L.
Attinger, Christopher E.
Evans, Karen K.
Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients
title Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients
title_full Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients
title_fullStr Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients
title_full_unstemmed Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients
title_short Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients
title_sort cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients
topic Extremity/Lymphedema
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007453/
https://www.ncbi.nlm.nih.gov/pubmed/33657778
http://dx.doi.org/10.5999/aps.2020.00549
work_keys_str_mv AT coerdtkathleenm cutaneousmucormycosisofthelowerextremityleadingamputationintwodiabeticpatients
AT zolperelizabethg cutaneousmucormycosisofthelowerextremityleadingamputationintwodiabeticpatients
AT starramyg cutaneousmucormycosisofthelowerextremityleadingamputationintwodiabeticpatients
AT fankennethl cutaneousmucormycosisofthelowerextremityleadingamputationintwodiabeticpatients
AT attingerchristophere cutaneousmucormycosisofthelowerextremityleadingamputationintwodiabeticpatients
AT evanskarenk cutaneousmucormycosisofthelowerextremityleadingamputationintwodiabeticpatients