Case for diagnosis. Dorsal nodule in a 10-year-old male()()

Granular cell tumors (GCTs) are rare soft-tissue neoplasms. GCT immunohistochemistry is positive for S-100, NSE, and CD68. This report describes the case of a 10-year-old male who presented with a dorsal nodule. A biopsy revealed aggregates and sheets of large epithelioid and spindle cells. The cell...

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Detalles Bibliográficos
Autores principales: Xu, Gongjun, Fu, Xuefeng, Fang, Jinxian, Huang, Chiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2021
Materias:
What Is Your Diagnosis?
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007480/
https://www.ncbi.nlm.nih.gov/pubmed/33579582
http://dx.doi.org/10.1016/j.abd.2020.08.009
Descripción
Sumario:Granular cell tumors (GCTs) are rare soft-tissue neoplasms. GCT immunohistochemistry is positive for S-100, NSE, and CD68. This report describes the case of a 10-year-old male who presented with a dorsal nodule. A biopsy revealed aggregates and sheets of large epithelioid and spindle cells. The cells had abundant eosinophilic granular cytoplasm. Immunohistochemical analysis was positive for CD68, NKI/C3, and synaptophysin; weakly positive for NSE; and negative for S-100, SOX10, HMB45, Melan A, cytokeratin, SMA, EMA, and CD163. The Ki-67 index was less than 1%. A diagnosis of an S-100 negative, cutaneous, benign GCT was determined.

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