Case for diagnosis. Dorsal nodule in a 10-year-old male()()

Granular cell tumors (GCTs) are rare soft-tissue neoplasms. GCT immunohistochemistry is positive for S-100, NSE, and CD68. This report describes the case of a 10-year-old male who presented with a dorsal nodule. A biopsy revealed aggregates and sheets of large epithelioid and spindle cells. The cell...

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Detalles Bibliográficos
Autores principales: Xu, Gongjun, Fu, Xuefeng, Fang, Jinxian, Huang, Chiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2021
Materias:
What Is Your Diagnosis?
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007480/
https://www.ncbi.nlm.nih.gov/pubmed/33579582
http://dx.doi.org/10.1016/j.abd.2020.08.009
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author Xu, Gongjun
Fu, Xuefeng
Fang, Jinxian
Huang, Chiqing
author_facet Xu, Gongjun
Fu, Xuefeng
Fang, Jinxian
Huang, Chiqing
author_sort Xu, Gongjun
collection PubMed
description Granular cell tumors (GCTs) are rare soft-tissue neoplasms. GCT immunohistochemistry is positive for S-100, NSE, and CD68. This report describes the case of a 10-year-old male who presented with a dorsal nodule. A biopsy revealed aggregates and sheets of large epithelioid and spindle cells. The cells had abundant eosinophilic granular cytoplasm. Immunohistochemical analysis was positive for CD68, NKI/C3, and synaptophysin; weakly positive for NSE; and negative for S-100, SOX10, HMB45, Melan A, cytokeratin, SMA, EMA, and CD163. The Ki-67 index was less than 1%. A diagnosis of an S-100 negative, cutaneous, benign GCT was determined.
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spelling pubmed-80074802021-04-01 Case for diagnosis. Dorsal nodule in a 10-year-old male()() Xu, Gongjun Fu, Xuefeng Fang, Jinxian Huang, Chiqing An Bras Dermatol What Is Your Diagnosis? Granular cell tumors (GCTs) are rare soft-tissue neoplasms. GCT immunohistochemistry is positive for S-100, NSE, and CD68. This report describes the case of a 10-year-old male who presented with a dorsal nodule. A biopsy revealed aggregates and sheets of large epithelioid and spindle cells. The cells had abundant eosinophilic granular cytoplasm. Immunohistochemical analysis was positive for CD68, NKI/C3, and synaptophysin; weakly positive for NSE; and negative for S-100, SOX10, HMB45, Melan A, cytokeratin, SMA, EMA, and CD163. The Ki-67 index was less than 1%. A diagnosis of an S-100 negative, cutaneous, benign GCT was determined. Sociedade Brasileira de Dermatologia 2021 2021-01-31 /pmc/articles/PMC8007480/ /pubmed/33579582 http://dx.doi.org/10.1016/j.abd.2020.08.009 Text en © 2021 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle What Is Your Diagnosis?
Xu, Gongjun
Fu, Xuefeng
Fang, Jinxian
Huang, Chiqing
Case for diagnosis. Dorsal nodule in a 10-year-old male()()
title Case for diagnosis. Dorsal nodule in a 10-year-old male()()
title_full Case for diagnosis. Dorsal nodule in a 10-year-old male()()
title_fullStr Case for diagnosis. Dorsal nodule in a 10-year-old male()()
title_full_unstemmed Case for diagnosis. Dorsal nodule in a 10-year-old male()()
title_short Case for diagnosis. Dorsal nodule in a 10-year-old male()()
title_sort case for diagnosis. dorsal nodule in a 10-year-old male()()
topic What Is Your Diagnosis?
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007480/
https://www.ncbi.nlm.nih.gov/pubmed/33579582
http://dx.doi.org/10.1016/j.abd.2020.08.009
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AT fangjinxian casefordiagnosisdorsalnoduleina10yearoldmale
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