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Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors
BACKGROUND: Increased sarcoma and melanoma risks after hereditary retinoblastoma are well established, whereas less is known about epithelial subsequent malignant neoplasms (SMNs) and risks for multiple (≥2) SMNs. METHODS: Leveraging long-term follow-up and detailed histologic information, we quanti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007574/ https://www.ncbi.nlm.nih.gov/pubmed/33473166 http://dx.doi.org/10.1038/s41416-020-01248-y |
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author | Schonfeld, Sara J. Kleinerman, Ruth A. Abramson, David H. Seddon, Johanna M. Tucker, Margaret A. Morton, Lindsay M. |
author_facet | Schonfeld, Sara J. Kleinerman, Ruth A. Abramson, David H. Seddon, Johanna M. Tucker, Margaret A. Morton, Lindsay M. |
author_sort | Schonfeld, Sara J. |
collection | PubMed |
description | BACKGROUND: Increased sarcoma and melanoma risks after hereditary retinoblastoma are well established, whereas less is known about epithelial subsequent malignant neoplasms (SMNs) and risks for multiple (≥2) SMNs. METHODS: Leveraging long-term follow-up and detailed histologic information, we quantified incident SMN risk among 1128 hereditary and 924 nonhereditary retinoblastoma survivors (diagnosed 1914–2006; follow-up through 2016). Standardised incidence ratios (SIRs) compared cancer risk after retinoblastoma relative to the general population. We estimated cumulative incidence accounting for competing risk of death. RESULTS: Hereditary survivors had statistically significantly increased SMN risk (N = 239; SIR = 11.9; 95% confidence interval [CI] 10.4–13.5), with SIRs >80-fold for sarcomas, nasal cavity tumours and pineoblastoma. Significantly increased risks were also observed for melanoma and central nervous system, oral cavity and breast SMNs (SIRs = 3.1–17), but not the uterus, kidney, lung, bladder, pancreas or other types. Cumulative incidence 50 years following hereditary retinoblastoma was 33.1% (95% CI 29.0–37.2) for a first SMN and 6.0% (95% CI 3.8–8.2) for a second SMN. SMN risk was not increased after nonhereditary retinoblastoma (N = 25; SIR = 0.8; 95% CI 0.5–1.2). CONCLUSION: Beyond the established sarcoma and melanoma risks after hereditary retinoblastoma, we demonstrate increased risk for a more limited number of epithelial malignancies than previously suggested. Cumulative incidence estimates emphasise long-term SMN burden after hereditary retinoblastoma. |
format | Online Article Text |
id | pubmed-8007574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80075742022-01-21 Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors Schonfeld, Sara J. Kleinerman, Ruth A. Abramson, David H. Seddon, Johanna M. Tucker, Margaret A. Morton, Lindsay M. Br J Cancer Article BACKGROUND: Increased sarcoma and melanoma risks after hereditary retinoblastoma are well established, whereas less is known about epithelial subsequent malignant neoplasms (SMNs) and risks for multiple (≥2) SMNs. METHODS: Leveraging long-term follow-up and detailed histologic information, we quantified incident SMN risk among 1128 hereditary and 924 nonhereditary retinoblastoma survivors (diagnosed 1914–2006; follow-up through 2016). Standardised incidence ratios (SIRs) compared cancer risk after retinoblastoma relative to the general population. We estimated cumulative incidence accounting for competing risk of death. RESULTS: Hereditary survivors had statistically significantly increased SMN risk (N = 239; SIR = 11.9; 95% confidence interval [CI] 10.4–13.5), with SIRs >80-fold for sarcomas, nasal cavity tumours and pineoblastoma. Significantly increased risks were also observed for melanoma and central nervous system, oral cavity and breast SMNs (SIRs = 3.1–17), but not the uterus, kidney, lung, bladder, pancreas or other types. Cumulative incidence 50 years following hereditary retinoblastoma was 33.1% (95% CI 29.0–37.2) for a first SMN and 6.0% (95% CI 3.8–8.2) for a second SMN. SMN risk was not increased after nonhereditary retinoblastoma (N = 25; SIR = 0.8; 95% CI 0.5–1.2). CONCLUSION: Beyond the established sarcoma and melanoma risks after hereditary retinoblastoma, we demonstrate increased risk for a more limited number of epithelial malignancies than previously suggested. Cumulative incidence estimates emphasise long-term SMN burden after hereditary retinoblastoma. Nature Publishing Group UK 2021-01-21 2021-03-30 /pmc/articles/PMC8007574/ /pubmed/33473166 http://dx.doi.org/10.1038/s41416-020-01248-y Text en © The Author(s), under exclusive licence to Cancer Research UK 2021 https://creativecommons.org/licenses/by/4.0/ Note This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0). |
spellingShingle | Article Schonfeld, Sara J. Kleinerman, Ruth A. Abramson, David H. Seddon, Johanna M. Tucker, Margaret A. Morton, Lindsay M. Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors |
title | Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors |
title_full | Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors |
title_fullStr | Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors |
title_full_unstemmed | Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors |
title_short | Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors |
title_sort | long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007574/ https://www.ncbi.nlm.nih.gov/pubmed/33473166 http://dx.doi.org/10.1038/s41416-020-01248-y |
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