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The deep and slow breathing characterizing rest favors brain respiratory-drive

A respiration-locked activity in the olfactory brain, mainly originating in the mechano-sensitivity of olfactory sensory neurons to air pressure, propagates from the olfactory bulb to the rest of the brain. Interestingly, changes in nasal airflow rate result in reorganization of olfactory bulb respo...

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Autores principales: Girin, Baptiste, Juventin, Maxime, Garcia, Samuel, Lefèvre, Laura, Amat, Corine, Fourcaud-Trocmé, Nicolas, Buonviso, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007577/
https://www.ncbi.nlm.nih.gov/pubmed/33782487
http://dx.doi.org/10.1038/s41598-021-86525-3
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author Girin, Baptiste
Juventin, Maxime
Garcia, Samuel
Lefèvre, Laura
Amat, Corine
Fourcaud-Trocmé, Nicolas
Buonviso, Nathalie
author_facet Girin, Baptiste
Juventin, Maxime
Garcia, Samuel
Lefèvre, Laura
Amat, Corine
Fourcaud-Trocmé, Nicolas
Buonviso, Nathalie
author_sort Girin, Baptiste
collection PubMed
description A respiration-locked activity in the olfactory brain, mainly originating in the mechano-sensitivity of olfactory sensory neurons to air pressure, propagates from the olfactory bulb to the rest of the brain. Interestingly, changes in nasal airflow rate result in reorganization of olfactory bulb response. By leveraging spontaneous variations of respiratory dynamics during natural conditions, we investigated whether respiratory drive also varies with nasal airflow movements. We analyzed local field potential activity relative to respiratory signal in various brain regions during waking and sleep states. We found that respiration regime was state-specific, and that quiet waking was the only vigilance state during which all the recorded structures can be respiration-driven whatever the respiratory frequency. Using CO(2)-enriched air to alter respiratory regime associated to each state and a respiratory cycle based analysis, we evidenced that the large and strong brain drive observed during quiet waking was related to an optimal trade-off between depth and duration of inspiration in the respiratory pattern, characterizing this specific state. These results show for the first time that changes in respiration regime affect cortical dynamics and that the respiratory regime associated with rest is optimal for respiration to drive the brain.
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spelling pubmed-80075772021-03-30 The deep and slow breathing characterizing rest favors brain respiratory-drive Girin, Baptiste Juventin, Maxime Garcia, Samuel Lefèvre, Laura Amat, Corine Fourcaud-Trocmé, Nicolas Buonviso, Nathalie Sci Rep Article A respiration-locked activity in the olfactory brain, mainly originating in the mechano-sensitivity of olfactory sensory neurons to air pressure, propagates from the olfactory bulb to the rest of the brain. Interestingly, changes in nasal airflow rate result in reorganization of olfactory bulb response. By leveraging spontaneous variations of respiratory dynamics during natural conditions, we investigated whether respiratory drive also varies with nasal airflow movements. We analyzed local field potential activity relative to respiratory signal in various brain regions during waking and sleep states. We found that respiration regime was state-specific, and that quiet waking was the only vigilance state during which all the recorded structures can be respiration-driven whatever the respiratory frequency. Using CO(2)-enriched air to alter respiratory regime associated to each state and a respiratory cycle based analysis, we evidenced that the large and strong brain drive observed during quiet waking was related to an optimal trade-off between depth and duration of inspiration in the respiratory pattern, characterizing this specific state. These results show for the first time that changes in respiration regime affect cortical dynamics and that the respiratory regime associated with rest is optimal for respiration to drive the brain. Nature Publishing Group UK 2021-03-29 /pmc/articles/PMC8007577/ /pubmed/33782487 http://dx.doi.org/10.1038/s41598-021-86525-3 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Girin, Baptiste
Juventin, Maxime
Garcia, Samuel
Lefèvre, Laura
Amat, Corine
Fourcaud-Trocmé, Nicolas
Buonviso, Nathalie
The deep and slow breathing characterizing rest favors brain respiratory-drive
title The deep and slow breathing characterizing rest favors brain respiratory-drive
title_full The deep and slow breathing characterizing rest favors brain respiratory-drive
title_fullStr The deep and slow breathing characterizing rest favors brain respiratory-drive
title_full_unstemmed The deep and slow breathing characterizing rest favors brain respiratory-drive
title_short The deep and slow breathing characterizing rest favors brain respiratory-drive
title_sort deep and slow breathing characterizing rest favors brain respiratory-drive
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007577/
https://www.ncbi.nlm.nih.gov/pubmed/33782487
http://dx.doi.org/10.1038/s41598-021-86525-3
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