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Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation

Cancer-associated fibroblasts (CAFs) contribute to malignant progression and chemoresistance in pancreatic ductal adenocarcinoma (PDAC). However, little is known about the underlying mechanism. In this study, we investigated the potential role and mechanisms of activating transcription factor 4 (ATF...

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Detalles Bibliográficos
Autores principales:	Wei, Lusheng, Lin, Qing, Lu, Yanan, Li, Guolin, Huang, Leyi, Fu, Zhiqiang, Chen, Rufu, Zhou, Quanbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007632/ https://www.ncbi.nlm.nih.gov/pubmed/33782384 http://dx.doi.org/10.1038/s41419-021-03574-2

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